ArticlePLoS medicine2010
Clinical benefits, costs, and cost-effectiveness of neonatal intensive care in Mexico.
Article in PLoS medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Prenatal exposure to cannabis and maternal and child health outcomes: a systematic review and meta-analysis.BMJ open · 2016Pooled it
- LUPS, A Novel Medium with Enhanced Diagnostic Sensitivity for Trichomonas vaginalis in Comparison with PEHPS and TYI-S-33.Acta parasitologica · 2026Observational
- Quality of cerebral palsy videos on Chinese social media platforms.Scientific reports · 2025Article
- Oxygen delivery and monitoring in neonatal intensive care units in Mexico in 2011 and in 2023: an observational longitudinal study.BMC nursing · 2024Article
- A Comparative Cross-sectional Study on Prevalence of Low Birth Weight and its Anticipated Risk Factors.Global pediatric health · 2023Article
- The Burden of Critical Illness in Hospitalized Children in Low- and Middle-Income Countries: Protocol for a Systematic Review and Meta-Analysis.Frontiers in pediatrics · 2022Article
- Distribution of under-5 deaths in the neonatal, postneonatal, and childhood periods: a multicountry analysis in 64 low- and middle-income countries.International journal for equity in health · 2021Article
- Direct costs of neonatal infection acquired in the community in full-term newborns and low risk at birth, Cundinamarca, ColombiaBiomedica : revista del Instituto Nacional de Salud · 2021Article
- Regional variation in cost of neonatal intensive care for extremely preterm infants.BMC pediatrics · 2021Article
- Global PARITY: Study Design for a Multi-Centered, International Point Prevalence Study to Estimate the Burden of Pediatric Acute Critical Illness in Resource-Limited Settings.Frontiers in pediatrics · 2021Article
- The potential economic value of a therapeutic Chagas disease vaccine for pregnant women to prevent congenital transmission.Vaccine · 2020Article
- Economic assessment of neonatal intensive care.Translational pediatrics · 2019Review
- Birth Hospitalization Costs and Days of Care for Mothers and Neonates in California, 2009-2011.The Journal of pediatrics · 2019Article
- Assessment of WINROP algorithm as screening tool for preterm infants in Manitoba to detect retinopathy of prematurity.Paediatrics & child health · 2017Article
- Lessons from the Design and Implementation of a Pediatric Critical Care and Emergency Medicine Training Program in a Low Resource Country-The South American Experience.Journal of pediatric intensive care · 2017Review
- Challenges and Priorities for Pediatric Critical Care Clinician-Researchers in Low- and Middle-Income Countries.Frontiers in pediatrics · 2017Article
- Preterm birth and its associations with residence and ambient vehicular traffic exposure.American journal of obstetrics and gynecology · 2016Article
- Case series of infants presenting with end stage retinopathy of prematurity to two tertiary eye care facilities in Mexico: underlying reasons for late presentation.Maternal and child health journal · 2015Article
- Economic analysis of a pediatric ventilator-associated pneumonia prevention initiative in nicaragua.International journal of pediatrics · 2012Article
- Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundNeonatal intensive care improves survival, but is associated with high costs and disability amongst survivors. Recent health reform in Mexico launched a new subsidized insurance program, necessitating informed choices on the different interventions that might be covered by the program, including neonatal intensive care. The purpose of this study was to estimate the clinical outcomes, costs, and cost-effectiveness of neonatal intensive care in Mexico. METHODS AND
findingsA cost-effectiveness analysis was conducted using a decision analytic model of health and economic outcomes following preterm birth. Model parameters governing health outcomes were estimated from Mexican vital registration and hospital discharge databases, supplemented with meta-analyses and systematic reviews from the published literature. Costs were estimated on the basis of data provided by the Ministry of Health in Mexico and World Health Organization price lists, supplemented with published studies from other countries as needed. The model estimated changes in clinical outcomes, life expectancy, disability-free life expectancy, lifetime costs, disability-adjusted life years (DALYs), and incremental cost-effectiveness ratios (ICERs) for neonatal intensive care compared to no intensive care. Uncertainty around the results was characterized using one-way sensitivity analyses and a multivariate probabilistic sensitivity analysis. In the base-case analysis, neonatal intensive care for infants born at 24-26, 27-29, and 30-33 weeks gestational age prolonged life expectancy by 28, 43, and 34 years and averted 9, 15, and 12 DALYs, at incremental costs per infant of US$11,400, US$9,500, and US$3,000, respectively, compared to an alternative of no intensive care. The ICERs of neonatal intensive care at 24-26, 27-29, and 30-33 weeks were US$1,200, US$650, and US$240, per DALY averted, respectively. The findings were robust to variation in parameter values over wide ranges in sensitivity analyses.
conclusionsIncremental cost-effectiveness ratios for neonatal intensive care imply very high value for money on the basis of conventional benchmarks for cost-effectiveness analysis. Please see later in the article for the Editors' Summary.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.