ArticlePloS one2010
Coxiella burnetii, the agent of Q fever, replicates within trophoblasts and induces a unique transcriptional response.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.
- Current approaches and developments in transcript profiling of the human placenta.Human reproduction update · 2020Pooled it
- [Long-term follow-up of a Coxiellosis outbreak in a goat flock].Tierarztliche Praxis. Ausgabe G, Grosstiere/Nutztiere · 2026Article
- Review
- Evidence ofNew microbes and new infections · 2025Review
- Q Fever Vaccines: Unveiling the Historical Journey and Contemporary Innovations in Vaccine Development.Vaccines · 2025Review
- Molecular examination for Coxiella burnetii and Brucella spp. infections in Iranian women experiencing spontaneous miscarriage.BMC infectious diseases · 2024Article
- Metabolism and physiology of pathogenic bacterial obligate intracellular parasites.Frontiers in cellular and infection microbiology · 2024Review
- Review
- Infection and Persistence ofInternational journal of molecular sciences · 2023Article
- Modulation of the E-cadherin in human cells infected in vitro with Coxiella burnetii.PloS one · 2023Article
- Role of Goats in the Epidemiology ofBiology · 2022Review
- Molecular detection of Coxiella-like endosymbionts and absence of Coxiella burnetii in Amblyomma mixtum from Veracruz, Mexico.Experimental & applied acarology · 2022Article
- Metabolic Plasticity Aids Amphotropism of Coxiella burnetii.Infection and immunity · 2021Article
- Acute Q fever in third trimester pregnancy.BMJ case reports · 2021Article
- FromPathogens (Basel, Switzerland) · 2021Review
- Review
- Defective Granuloma Formation in Elderly Infected Patients.Frontiers in cellular and infection microbiology · 2020Article
- Pregnancy outcomes of Q fever: prospective follow-up study on Reunion island.BMC infectious diseases · 2019Article
- Article
- Full-Term Human Placental Macrophages EliminateFrontiers in microbiology · 2019Article
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Q fever is a zoonosis caused by Coxiella burnetii, an obligate intracellular bacterium typically found in myeloid cells. The infection is a source of severe obstetrical complications in humans and cattle and can undergo chronic evolution in a minority of pregnant women. Because C. burnetii is found in the placentas of aborted fetuses, we investigated the possibility that it could infect trophoblasts. Here, we show that C. burnetii infected and replicated in BeWo trophoblasts within phagolysosomes. Using pangenomic microarrays, we found that C. burnetii induced a specific transcriptomic program. This program was associated with the modulation of inflammatory responses that were shared with inflammatory agonists, such as TNF, and more specific responses involving genes related to pregnancy development, including EGR-1 and NDGR1. In addition, C. burnetii stimulated gene networks organized around the IL-6 and IL-13 pathways, which both modulate STAT3. Taken together, these results revealed that trophoblasts represent a protective niche for C. burnetii. The activation program induced by C. burnetii in trophoblasts may allow bacterial replication but seems unable to interfere with the development of normal pregnancy. Such pathophysiologocal processes should require the activation of immune placental cells associated with trophoblasts.
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