ArticleMolecular vision2010
CyclinD1 protein expressed in pterygia is associated with β-catenin protein localization.
Article in Molecular vision, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Therapeutic Potential of Graphene Quantum Dots on Pterygium Cells.Investigative ophthalmology & visual science · 2025Article
- Enhancing the efficacy of letrozole-loaded PEGylated nanoliposomes against breast cancer cells:Heliyon · 2024Article
- Claudin-7 deficiency promotes stemness properties in colorectal cancer through Sox9-mediated Wnt/β-catenin signalling.Journal of translational medicine · 2021Article
- Analysis of WWOX gene expression and protein levels in pterygium.International ophthalmology · 2020Article
- Identification of pterygium-related mRNA expression profiling by microarray analysis.Eye (London, England) · 2017Article
- Aberrant expression of genes and proteins in pterygium and their implications in the pathogenesis.International journal of ophthalmology · 2017Review
- Evaluation of tumor metastasis-associated markers for molecular classification in patients with esophageal squamous cell carcinoma.International journal of clinical and experimental medicine · 2015Article
- Expression of WW domain-containing oxidoreductase WWOX in pterygium.Molecular vision · 2015Article
- MiRNA-221 negatively regulated downstream p27Kip1 gene expression involvement in pterygium pathogenesis.Molecular vision · 2014Article
- Ataxia-telangiectasia group D complementing gene (ATDC) promotes lung cancer cell proliferation by activating NF-κB pathway.PloS one · 2013Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe Wnt (Wg/Wnt) signaling cascade plays an important role in tumorigenesis. Our previous report indicated that aberrant localization of β-catenin proteins was a feature of pterygia. Therefore, this study aimed to analyze the association of β-catenin protein and expression of a downstream gene, cyclin D1, in pterygial tissues.
methodsUsing immunohistochemistry, β-catenin and cyclin D1 protein expression was studied, in 150 pterygial specimens and 30 normal conjunctivas.
resultsSeventy-three (48.7%) and 60 (40.0%) pterygial specimens tested positive for β-catenin and cyclin D1 protein expression, respectively. Cyclin D1protein expression was significantly higher in β-catenin-nuclear/cytoplasmic positive groups than in β-catenin membrane positive and negative groups (p < 0.0001). In addition, cyclin D1 expression was significantly higher in the fleshy group than in the atrophic and intermediate groups (p = 0.006).
conclusionsOur study demonstrated that β-catenin expressed in nuclei/cytoplasm increases cyclinD1 protein expression, which invokes pterygial cell proliferation.
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21179427PMC3003710What OpenQuestion holds
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