ArticlePloS one2010
The therapeutic implications of plasticity of the cancer stem cell phenotype.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 62 citations in OpenAlex.
- MicroRNA-222 Regulates Melanoma Plasticity.Journal of clinical medicine · 2020Article
- Article
- Effect of cellular de-differentiation on the dynamics and evolution of tissue and tumor cells in mathematical models with feedback regulation.Journal of theoretical biology · 2018Article
- Breast cancer complexity: implications of intratumoral heterogeneity in clinical management.Cancer metastasis reviews · 2017Review
- Induced cancer stem cells generated by radiochemotherapy and their therapeutic implications.Oncotarget · 2017Review
- Breast cancer stem cell: the roles and therapeutic implications.Cellular and molecular life sciences : CMLS · 2017Review
- Stem Cell Plasticity and Niche Dynamics in Cancer Progression.IEEE transactions on bio-medical engineering · 2017Article
- Oncometabolic Nuclear Reprogramming of Cancer Stemness.Stem cell reports · 2016Article
- A mathematical model of tumor growth and its response to single irradiation.Theoretical biology & medical modelling · 2016Article
- Cancer Stem Cell Plasticity as Tumor Growth Promoter and Catalyst of Population Collapse.Stem cells international · 2016Article
- Therapeutic Implications of Cellular Heterogeneity and Plasticity in Breast Cancer.Cell stem cell · 2015Review
- Evolution and phenotypic selection of cancer stem cells.PLoS computational biology · 2015Article
- Episensitization: Defying Time's Arrow.Frontiers in oncology · 2015Review
- A multicompartment mathematical model of cancer stem cell-driven tumor growth dynamics.Bulletin of mathematical biology · 2014Article
- Effect of dedifferentiation on time to mutation acquisition in stem cell-driven cancers.PLoS computational biology · 2014Article
- Optimization of high grade glioma cell culture from surgical specimens for use in clinically relevant animal models and 3D immunochemistry.Journal of visualized experiments : JoVE · 2014Article
- Article
- Microenvironmental variables must influence intrinsic phenotypic parameters of cancer stem cells to affect tumourigenicity.PLoS computational biology · 2014Article
- Aiming to immune elimination of ovarian cancer stem cells.World journal of stem cells · 2013Review
- Plasticity of tumour and immune cells: a source of heterogeneity and a cause for therapy resistance?Nature reviews. Cancer · 2013Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The cancer stem cell hypothesis suggests that tumors contain a small population of cancer cells that have the ability to undergo symmetric self-renewing cell division. In tumors that follow this model, cancer stem cells produce various kinds of specified precursors that divide a limited number of times before terminally differentiating or undergoing apoptosis. As cells within the tumor mature, they become progressively more restricted in the cell types to which they can give rise. However, in some tumor types, the presence of certain extra- or intracellular signals can induce committed cancer progenitors to revert to a multipotential cancer stem cell state. In this paper, we design a novel mathematical model to investigate the dynamics of tumor progression in such situations, and study the implications of a reversible cancer stem cell phenotype for therapeutic interventions. We find that higher levels of dedifferentiation substantially reduce the effectiveness of therapy directed at cancer stem cells by leading to higher rates of resistance. We conclude that plasticity of the cancer stem cell phenotype is an important determinant of the prognosis of tumors. This model represents the first mathematical investigation of this tumor trait and contributes to a quantitative understanding of cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.