Evidence map›Paper›PMID 21179397›Full record

ArticleAcademic journal of Xian Jiaotong University : AJXJTU = Xi'an jiao tong da xue xue bao (Yi wen ban)2004

Fine Mapping of a Deafness Mutation hml on Mouse Chromosome 10.

Qing Yin Zheng, Belinda S Harris, Patricia F Ward-Bailey, Heping Yu, Roderick T Bronson, Muriel T Davisson, Kenneth R Johnson

Abstract read
In one paragraph

Article in Academic journal of Xian Jiaotong University : AJXJTU = Xi'an jiao tong da xue xue bao (Yi wen ban), 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Qing Yin ZhengThe Jackson Laboratory, Bar Harbor, Maine 04609, USA.
Belinda S Harris
Patricia F Ward-Bailey
Heping Yu
Roderick T Bronson
Muriel T Davisson
Kenneth R Johnson

Funding

Transcriptome and Proteome Analysis of Mouse Inner EarsR01DC007392 · NIDCD · JACKSON LABORATORY · PI ZHENG, QING Y · 2005 to 2007
$1.0M
Identify and Develop Mouse Models for Otitis MediaR21DC005846 · NIDCD · JACKSON LABORATORY · PI ZHENG, QING Y · 2003 to 2005
$562k
GENETICS OF A NEW MOUSE MODEL FOR DEAFNESSR03DC004376 · NIDCD · JACKSON LABORATORY · PI ZHENG, QING Y · 2000 to 2002
$248k
NIDCD NIH HHS R01 DC007392NIDCD NIH HHS R03 DC004376NIDCD NIH HHS R21 DC005846
6 · The paper itself

Abstract

objectiveto map a mouse deafness gene, identify the underlying mutation and develop a mouse model for human deafness.

methodsgenetic linkage cross and genome scan were used to map a novel mutation named hypoplasia of the membranous labyrinth (hml), which causes hearing loss in mutant mice.

results1. hml was mapped on mouse Chr 10 (~43 cM from the centromere) suggests that the homologous human gene is on 12q22-q24, which was defined on the basis of known mouse-human homologies (OMIM, 2004). 2. This study has generated 25 polymorphic microsatellite markers, placed 3 known human genes in the correct order in a high-resolution mouse map and narrowed the hml candidate gene region to a 500kb area.

Identifiers

PMID21179397
PMCPMC3004367

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.