ArticleScientia pharmaceutica
Contribution of thromboxane a₂ in rat common carotid artery response to serotonin.
Article in Scientia pharmaceutica. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 10 citations in OpenAlex.
- The combination of dantrolene and nimodipine effectively reduces 5-HT-induced vasospasms in diabetic rats.Scientific reports · 2021Article
- Brain changes associated with thromboxane receptor antagonist SQ 29,548 treatment in a mouse model.Journal of neuroscience research · 2015Article
- Therapeutic approach in the improvement of endothelial dysfunction: the current state of the art.BioMed research international · 2013Review
- Serotonin and blood pressure regulation.Pharmacological reviews · 2012Review
- Pharmacological analysis of the rat femoral artery response to bradykinin.Scientia pharmaceuticaArticle
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Authors and funding
3 authors at 1 institution in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Serotonin is a vasoactive substance that in different blood vessels mostly induces vasoconstriction. Considering the important role of common carotid artery in brain blood supply, the aims of this study were to investigate the effect of serotonin on isolated rat common carotid artery and also to examine participation of intact endothelium, cyclooxygenase products, Ca(++) channels and 5-HT(2) receptors in serotonin-evoked action. Endothelium was mechanically removed from some vascular rings. Circular artery segments were placed in organ baths containing KrebsâRinger bicarbonate solution. Cumulative concentration-contraction curves for serotonin were obtained in rings previously equilibrated at basal tone. Serotonin produced concentration-dependent contraction, which was unaltered by endothelial denudation. Serotonin-induced effect was notably and comparably reduced by indomethacin (cyclooxygenase inhibitor) or OKYâ046 (thromboxane A(2)-synthase inhibitor) on intact or denuded rings. Nifedipine (Ca(++) channel blocker) or ketanserin (5-HT(2) receptor antagonist) strongly reduced serotonin-evoked effect. Our results suggest that serotonin produced concentration-dependent and endothelium-independent contraction of carotid artery, which was initiated by activation of 5-HT(2) receptors located on smooth muscle cells and mediated via L-type Ca(++) channels. Thromboxane A(2) from smooth muscle cells notably contributed to the overall contraction of carotid artery induced by serotonin.
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