ArticleMolecular vision2010
Stability of active zone components at the photoreceptor ribbon complex.
Article in Molecular vision, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed.
- Ankyrin-B and ankyrin-G are required for synaptic integrity in the mouse outer retina.PNAS nexus · 2026Article
- Cadherin-16 regulates acoustic sensory gating in zebrafish through endocrine signaling.PLoS biology · 2025Article
- A non-conducting role of the CaeLife · 2024Article
- Cadherin 16 promotes sensory gating via the endocrine corpuscles of Stannius.bioRxiv : the preprint server for biology · 2024Article
- A non-conducting role of the CabioRxiv : the preprint server for biology · 2024Article
- Article
- Calcium Channels in Retinal Function and Disease.Annual review of vision science · 2022Review
- VGLUT3-p.A211V variant fuses stereocilia bundles and elongates synaptic ribbons.The Journal of physiology · 2021Article
- Impaired CaInternational journal of molecular sciences · 2021Article
- Molecular Assembly and Structural Plasticity of Sensory Ribbon Synapses-A Presynaptic Perspective.International journal of molecular sciences · 2020Review
- Angiotensin-Receptor-Associated Protein Modulates CaScientific reports · 2019Article
- αThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Analysis of RIM Expression and Function at Mouse Photoreceptor Ribbon Synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Article
- Pituitary Adenylate Cyclase Activating Polypeptide, A Potential Therapeutic Agent for Diabetic Retinopathy in Rats: Focus on the Vertical Information Processing Pathway.Neurotoxicity research · 2016Article
- Cochlear Synaptopathy and Noise-Induced Hidden Hearing Loss.Neural plasticity · 2016Review
- RIM1/2-Mediated Facilitation of Cav1.4 Channel Opening Is Required for Ca2+-Stimulated Release in Mouse Rod Photoreceptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Zebrafish Cacna1fa is required for cone photoreceptor function and synaptic ribbon formation.Human molecular genetics · 2014Article
- Presynaptic [Ca(2+)] and GCAPs: aspects on the structure and function of photoreceptor ribbon synapses.Frontiers in molecular neuroscience · 2014Review
- Evidence for a Clathrin-independent mode of endocytosis at a continuously active sensory synapse.Frontiers in cellular neuroscience · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposePhotoreceptor ribbon synapses translate light-dependent changes of membrane potential into graded transmitter release over several orders of magnitude in intensity. A specialized organelle at the active zone--the synaptic ribbon--is a key player in this process, and it is well known that the ribbon undergoes illumination and thus activity-dependent structural changes. However, the molecular basis for these changes is unknown. The aim of this study was to correlate the known ultrastructural ribbon changes to the distribution of proteins of the presynaptic ribbon complex.
methodsIn an in vitro assay, two distinct structural ribbon states--club-shaped and spherical-shaped--were enriched and the distribution of presynaptic proteins at the rod photoreceptor ribbon complex was analyzed with immunocytochemistry and light and electron microscopy.
resultsWe show that structural changes of the ribbon correlate with the redistribution of selected presynaptic proteins. The disassembly of the ribbon complex seems to be a multistep process, which starts with the removal of spherical ribbon material while arciform density and active zone plasma membrane proteins remain largely unchanged at their synaptic location. Only later, in a second phase following the removal of ribbon material, the arciform density and plasma membrane proteins are redistributed from their synaptic localization and active zones disappear.
conclusionsThe results of our study show that photoreceptor ribbon and arciform density/plasma membrane components might be influenced differentially by activity-driven processes, thus providing a molecular basis for further investigation of regulatory and adaptive processes in photoreceptor ribbon synaptic transmission.
Indexed as
Identifiers
21179232PMC3002953What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.