ArticleGenes and immunity2011
A genome-wide admixture scan for ancestry-linked genes predisposing to sarcoidosis in African-Americans.
Article in Genes and immunity, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 37 citations in OpenAlex.
- Replication of genetic loci for sarcoidosis in US black women: data from the Black Women's Health Study.Human genetics · 2013Trial
- Large-scale admixture mapping in the All of Us Research Program improves the characterization of cross-population phenotypic differences.Nature communications · 2026Article
- Identification of Environmental Exposures Associated with Risk of Sarcoidosis in African Americans.Annals of the American Thoracic Society · 2023Article
- Sex differences in the genetics of sarcoidosis across European and African ancestry populations.Frontiers in medicine · 2023Article
- Recent advances in sarcoidosis genomics: epigenetics, gene expression, and gene by environment (G × E) interaction studies.Current opinion in pulmonary medicine · 2020Review
- Extended methods for gene-environment-wide interaction scans in studies of admixed individuals with varying degrees of relationships.Genetic epidemiology · 2019Article
- Common variants of T-cells contribute differently to phenotypic variation in sarcoidosis.Scientific reports · 2017Article
- Granuloma genes in sarcoidosis: what is new?Current opinion in pulmonary medicine · 2015Review
- Association of HLA-DRB1 with Sarcoidosis Susceptibility and Progression in African Americans.American journal of respiratory cell and molecular biology · 2015Article
- Admixture mapping identifies a quantitative trait locus associated with FEV1/FVC in the COPDGene Study.Genetic epidemiology · 2014Article
- Efficient generalized least squares method for mixed population and family-based samples in genome-wide association studies.Genetic epidemiology · 2014Article
- Admixture fine-mapping in African Americans implicates XAF1 as a possible sarcoidosis risk gene.PloS one · 2014Article
- Admixture mapping of prostate cancer in African Americans participating in the North Carolina-Louisiana Prostate Cancer Project (PCaP).The Prostate · 2014Article
- Expression and sub-cellular localization of an epigenetic regulator, co-activator arginine methyltransferase 1 (CARM1), is associated with specific breast cancer subtypes and ethnicity.Molecular cancer · 2013Article
- Extending admixture mapping to nuclear pedigrees: application to sarcoidosis.Genetic epidemiology · 2013Article
- Association of ANXA11 genetic variation with sarcoidosis in African Americans and European Americans.Genes and immunity · 2013Article
- Genome-wide linkage analysis of cardiovascular disease biomarkers in a large, multigenerational family.PloS one · 2013Article
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
Abstract
Genome-wide linkage and association studies have uncovered variants associated with sarcoidosis, a multiorgan granulomatous inflammatory disease. African ancestry may influence disease pathogenesis, as African-Americans are more commonly affected by sarcoidosis. Therefore, we conducted the first sarcoidosis genome-wide ancestry scan using a map of 1384 highly ancestry-informative single-nucleotide polymorphisms genotyped on 1357 sarcoidosis cases and 703 unaffected controls self-identified as African-American. The most significant ancestry association was at marker rs11966463 on chromosome 6p22.3 (ancestry association risk ratio (aRR)=1.90; P=0.0002). When we restricted the analysis to biopsy-confirmed cases, the aRR for this marker increased to 2.01; P=0.00007. Among the eight other markers that demonstrated suggestive ancestry associations with sarcoidosis were rs1462906 on chromosome 8p12, which had the most significant association with European ancestry (aRR=0.65; P=0.002), and markers on chromosomes 5p13 (aRR=1.46; P=0.005) and 5q31 (aRR=0.67; P=0.005), which correspond to regions we previously identified through sib-pair linkage analyses. Overall, the most significant ancestry association for Scadding stage IV cases was to marker rs7919137 on chromosome 10p11.22 (aRR=0.27; P=2 × 10(-5)), a region not associated with disease susceptibility. In summary, through admixture mapping of sarcoidosis we have confirmed previous genetic linkages and identified several novel putative candidate loci for sarcoidosis.
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