ArticleBritish journal of cancer2011
Toll-like receptor 2 is present in the microenvironment of oral squamous cell carcinoma.
Article in British journal of cancer, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 44 citations in OpenAlex.
- Identification of Novel Hub Genes and Potential Signaling Pathways with the Pathogenesis of Oral Cavity Squamous Cell Carcinoma Based on Bioinformatics Analysis.Cancer informatics · 2026Article
- Influence of Paratuberculosis Vaccination on the Local Immune Response in Experimentally Infected Calves: An Immunohistochemical Analysis.Animals : an open access journal from MDPI · 2025Article
- Toll-like receptors in health and disease.MedComm · 2024Review
- Role of toll-like receptor in the pathogenesis of oral cancer.Cell biochemistry and biophysics · 2024Review
- Role of N6-methyladenosine methylation in head and neck cancer and its regulation of innate immune pathways.Frontiers in immunology · 2024Review
- The HPV viral regulatory mechanism of TLRs and the related treatments for HPV-associated cancers.Frontiers in immunology · 2024Review
- Toll-like receptor-guided therapeutic intervention of human cancers: molecular and immunological perspectives.Frontiers in immunology · 2023Review
- Association between Tissue Expression of Toll-Like Receptor and Some Clinicopathological Indices in Oral Squamous Cell Carcinoma.Reports of biochemistry & molecular biology · 2022Article
- Evidence of a role for interleukin-6 in anoikis resistance in oral squamous cell carcinoma.Medical oncology (Northwood, London, England) · 2022Article
- Genes and pathways monotonically dysregulated during progression from normal through leukoplakia to gingivo-buccal oral cancer.NPJ genomic medicine · 2021Article
- The effect of smoking on clinical presentation and expression of TLR-2 and CD34 in Oral lichen Planus patients: clinical and immunohistochemical study.BMC oral health · 2020Article
- Toll-like receptors: exploring their potential connection with post-operative infectious complications and cancer recurrence.Clinical & experimental metastasis · 2020Review
- Role of Toll like receptor in progression and suppression of oral squamous cell carcinoma.Oncology reviews · 2020Article
- Insights Into Lung Cancer Immune-Based Biology, Prevention, and Treatment.Frontiers in immunology · 2020Review
- TLR2 deficiency enhances susceptibility to oral carcinogenesis by promoting an inflammatory environment.American journal of cancer research · 2019Article
- Evaluation of Toll-Like Receptor Expression with Clinicopathologic Variables in Endometrium Cancer.Sisli Etfal Hastanesi tip bulteni · 2018Article
- Viral Modulation of TLRs and Cytokines and the Related Immunotherapies for HPV-Associated Cancers.Journal of immunology research · 2018Review
- Crosstalk between the HIF-1 and Toll-like receptor/nuclear factor-κB pathways in the oral squamous cell carcinoma microenvironment.Oncotarget · 2016Article
- Targeting Toll-like receptor 2 inhibits growth of head and neck squamous cell carcinoma.Oncotarget · 2015Article
- Toll-like receptors and cancer, particularly oral squamous cell carcinoma.Frontiers in immunology · 2014Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of this study was to investigate the expression of toll-like receptor 2 (TLR2) on cells associated with oral squamous cell carcinoma, epithelial dysplasia and irritative hyperplasia, using immunohistochemistry.
resultsMore immune cells expressed TLR2 in carcinoma and dysplasia than in hyperplasia (P<0.001). No hyperplastic samples showed positive TLR2 staining on keratinocytes, whereas keratinocytes in 64% of cases of carcinoma and 74% of cases of dysplasia were TLR2 positive.
conclusionPositive TLR2 expression in the microenvironment suggests activation of immune surveillance against the altered epithelium, whereas TLR2 expression by malignant keratinocytes may be indicative of resistance to apoptosis as a pro-survival mechanism.
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