ArticleMolecular systems biology2010
Design principles of nuclear receptor signaling: how complex networking improves signal transduction.
Article in Molecular systems biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 38 citations in OpenAlex.
- Hallmarks of disease: how tuned hierarchies of intelligent molecular neural networks (MNNs) may matter.Endocrine-related cancer · 2026Review
- ROS networks: designs, aging, Parkinson's disease and precision therapies.NPJ systems biology and applications · 2020Article
- Thyroid hormone receptor localization in target tissues.The Journal of endocrinology · 2018Review
- Linking physiologically-based pharmacokinetic and genome-scale metabolic networks to understand estradiol biology.BMC systems biology · 2017Article
- The Peculiar Glycolytic Pathway in Hyperthermophylic Archaea: Understanding Its Whims by Experimentation In Silico.International journal of molecular sciences · 2017Article
- Glucocorticoid receptor isoforms direct distinct mitochondrial programs to regulate ATP production.Scientific reports · 2016Article
- MUFINS: multi-formalism interaction network simulator.NPJ systems biology and applications · 2016Article
- A simple kinetic model with explicit predictions for nuclear transport.Biophysical journal · 2013Article
- Higher nucleoporin-Importinβ affinity at the nuclear basket increases nucleocytoplasmic import.PloS one · 2013Article
- Optimization of stress response through the nuclear receptor-mediated cortisol signalling network.Nature communications · 2013Article
- Understanding complexity in neurodegenerative diseases: in silico reconstruction of emergence.Frontiers in physiology · 2012Article
- Characterization of rhodamine-123 as a tracer dye for use in in vitro drug transport assays.PloS one · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 8 institutions in 5 countries.
Funding
Abstract
The topology of nuclear receptor (NR) signaling is captured in a systems biological graphical notation. This enables us to identify a number of 'design' aspects of the topology of these networks that might appear unnecessarily complex or even functionally paradoxical. In realistic kinetic models of increasing complexity, calculations show how these features correspond to potentially important design principles, e.g.: (i) cytosolic 'nuclear' receptor may shuttle signal molecules to the nucleus, (ii) the active export of NRs may ensure that there is sufficient receptor protein to capture ligand at the cytoplasmic membrane, (iii) a three conveyor belts design dissipating GTP-free energy, greatly aids response, (iv) the active export of importins may prevent sequestration of NRs by importins in the nucleus and (v) the unspecific nature of the nuclear pore may ensure signal-flux robustness. In addition, the models developed are suitable for implementation in specific cases of NR-mediated signaling, to predict individual receptor functions and differential sensitivity toward physiological and pharmacological ligands.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.