ReviewCurrent opinion in nephrology and hypertension2011
Estrogen, hormonal replacement therapy and cardiovascular disease.
Review in Current opinion in nephrology and hypertension, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04894318 (The Short Term Beneficıal Effects Of A Low-Fat And Low-Cholesterol Dietary Intervention On LDL Sub-Groups In Dyslipidemic Turkish Patients), which is not on this map. Cited by 134 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Short Term Beneficıal Effects Of A Low-Fat And Low-Cholesterol Dietary Intervention On LDL Sub-Groups In Dyslipidemic Turkish Patients
Who cites it
134 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Sex differences in the association between marital status and the risk of cardiovascular, cancer, and all-cause mortality: a systematic review and meta-analysis of 7,881,040 individuals.Global health research and policy · 2020Pooled it
- Resting blood pressure reductions following handgrip exercise training and the impact of age and sex: a systematic review and narrative synthesis.Systematic reviews · 2018Pooled it
- Management of Primary Ovarian Insufficiency Symptoms in Survivors of Childhood and Adolescent Cancer.Journal of the National Comprehensive Cancer Network : JNCCN · 2018Pooled it
- High progesterone levels are associated with family history of premature coronary artery disease in young healthy adult men.PloS one · 2019Trial
- Genistein Supplementation and Cardiac Function in Postmenopausal Women with Metabolic Syndrome: Results from a Pilot Strain-Echo Study.Nutrients · 2017Trial
- Hepatic Effects of Estrogen on Plasma Distribution of Small Dense Low-Density Lipoprotein and Free Radical Production in Postmenopausal Women.Journal of atherosclerosis and thrombosis · 2016Trial
- Association between diabetes and tinnitus traits in the UK Biobank: a population-based cohort study.Acta diabetologica · 2026Article
- Sex hormone-binding globulin and coronary heart disease: a narrative review of associations and biomarker potential.Journal of thoracic disease · 2026Review
- Female Dahl, but Not SS13Research square · 2026Article
- Metabolomic Profiles of Inflammation Associated With Incident Ischemic Stroke Risk in Women.Neurology · 2026Article
- Transdermal Hormonal Therapy in Menopause: Current Evidence and Personalized Approaches.Pharmaceutics · 2026Review
- Therapeutic Effects of Fermented Soy Extract on Osteoporotic Changes in Ovariectomized Mice as a Model of Menopause.Molecular nutrition & food research · 2026Article
- An IL6 variant -174 G-C alters cardiac hypertrophy but not cardiometabolic responses to HFD in mice.npj metabolic health and disease · 2026Article
- Cardiac ventricular Kir6.1 ATP-sensitive potassium channels: an overlooked effector of cardioprotection.Frontiers in physiology · 2026Article
- Reproductive history, menopause and cardiometabolic health in women: a multicountry analysis.Journal of epidemiology and community health · 2025Article
- Estrogen Inhibits the Phenotypic Switching of Vascular Smooth Muscle Cells through ER-α/CREB in Aortic Dissection.ACS omega · 2025Article
- Transport functions of intestinal lymphatic vessels.Nature reviews. Gastroenterology & hepatology · 2025Review
- Epigenetic Regulation of Innate and Adaptive Immune Cells in Salt-Sensitive Hypertension.Circulation research · 2025Review
- Interaction of GPER-1 with the endocrine signaling axis in breast cancer.Frontiers in endocrinology · 2025Review
- Decreased blood pressure with acute administration of quercetin in L-NAME-induced hypertensive rats.Basic & clinical pharmacology & toxicology · 2025Article
74 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
purpose of reviewPremenopausal women have a lower risk and incidence of hypertension and cardiovascular disease (CVD) compared to age-matched men and this sex advantage for women gradually disappears after menopause, suggesting that sexual hormones play a cardioprotective role in women. However, randomized prospective primary or secondary prevention trials failed to confirm that hormone replacement therapy (HRT) affords cardioprotection. This review highlights the factors that may contribute to this divergent outcome and could reveal why young or premenopausal women are protected from CVD and yet postmenopausal women do not benefit from HRT. RECENT
findingsIn addition to the two classical estrogen receptors, ERα and ERβ, a third, G-protein-coupled estrogen receptor GPR30, has been identified. New intracellular signaling pathways and actions for the cardiovascular protective properties of estrogen have been proposed. In addition, recent Women's Health Initiative (WHI) studies restricted to younger postmenopausal women showed that initiation of HRT closer to menopause reduced the risk of CVD. Moreover, dosage, duration, the type of estrogen and route of administration all merit consideration when determining the outcome of HRT. SUMMARY: HRT has become one of the most controversial topics related to women's health. Future studies are necessary if we are to understand the divergent published findings regarding HRT and develop new therapeutic strategies to improve the quality of life for women.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.