ArticleVirulence
SNARE motif: a common motif used by pathogens to manipulate membrane fusion.
Article in Virulence. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Genome-wide association meta-analysis of coronary artery disease and periodontitis reveals a novel shared risk locus.Scientific reports · 2018Pooled it
- IsoformSwitchAnalyzeR v2: analysis of functional isoform changes in long-read and single-cell sequencing data.NAR genomics and bioinformatics · 2026Article
- Natural and evolved membrane-associated accessory proteins differentially engage SNARE machinery for AAV egress.Journal of virology · 2026Article
- SNARE mimicry by the CD225 domain of IFITM3 enables regulation of homotypic late endosome fusion.bioRxiv : the preprint server for biology · 2024Article
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- SNARE Modulators and SNARE Mimetic Peptides.Biomolecules · 2022Review
- Engineering artificial photosynthetic life-forms through endosymbiosis.Nature communications · 2022Article
- Looking for pathways related to COVID-19: confirmation of pathogenic mechanisms by SARS-CoV-2-host interactome.Cell death & disease · 2021Article
- Peptide Triazole Thiol Irreversibly Inactivates Metastable HIV-1 Env by Accessing Conformational Triggers Intrinsic to Virus-Cell Entry.Microorganisms · 2021Article
- Macrophage Proteome Analysis at Different Stages ofProteomes · 2021Article
- Genome-guided analysis allows the identification of novel physiological traits in Trichococcus species.BMC genomics · 2020Article
- Toward a Synthetic Yeast Endosymbiont with a Minimal Genome.Journal of the American Chemical Society · 2019Article
- Structural basis for the homotypic fusion of chlamydial inclusions by the SNARE-like protein IncA.Nature communications · 2019Article
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- Engineering yeast endosymbionts as a step toward the evolution of mitochondria.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- NLR surveillance of essential SEC-9 SNARE proteins induces programmed cell death upon allorecognition in filamentous fungi.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Aspergillus flavus infection triggered immune responses and host-pathogen cross-talks in groundnut during in-vitro seed colonization.Scientific reports · 2017Article
- Exploitation of the Host Cell Membrane Fusion Machinery by Leishmania Is Part of the Infection Process.PLoS pathogens · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
To penetrate host cells through their membranes, pathogens use a variety of molecular components in which the presence of heptad repeat motifs seems to be a prevailing element. Heptad repeats are characterized by a pattern of seven, generally hydrophobic, residues. In order to initiate membrane fusion, viruses use glycoproteins-containing heptad repeats. These proteins are structurally and functionally similar to the SNARE proteins known to be involved in eukaryotic membrane fusion. SNAREs also display a heptad repeat motif called the "SNARE motif". As bacterial genomes are being sequenced, microorganisms also appear to be carrying membrane proteins resembling eukaryotic SNAREs. This category of SNARE-like proteins might share similar functions and could be used by microorganisms to either promote or block membrane fusion. Such a recurrence across pathogenic organisms suggests that this architectural motif was evolutionarily selected because it most effectively ensures the survival of pathogens within the eukaryotic environment.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.