ArticleVirulence
Role of luxS in Bacillus anthracis growth and virulence factor expression.
Article in Virulence. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 29 citations in OpenAlex.
- Regulatory mechanisms of quorum sensing in microbial communities and their potential applications in ruminant livestock production.Journal of advanced research · 2026Review
- Pathogenicity and virulence ofVirulence · 2023Review
- 1,8-Cineole inhibits biofilm formation and bacterial pathogenicity by suppressingFrontiers in pharmacology · 2022Article
- Regulatory Mechanisms of the LuxS/AI-2 System and Bacterial Resistance.Antimicrobial agents and chemotherapy · 2019Review
- A Quorum Sensing-Regulated Protein Binds Cell Wall Components and Enhances Lysozyme Resistance in Streptococcus pyogenes.Journal of bacteriology · 2018Article
- Overexpression ofFrontiers in microbiology · 2018Article
- Modeling Rabbit Responses to Single and Multiple Aerosol Exposures of Bacillus anthracis Spores.Risk analysis : an official publication of the Society for Risk Analysis · 2017Article
- Transcriptome analysis identifies Bacillus anthracis genes that respond to CO2 through an AtxA-dependent mechanism.BMC genomics · 2014Article
- A chemical biology approach to interrogate quorum-sensing regulated behaviors at the molecular and cellular level.Chemistry & biology · 2013Article
- Targeting agr- and agr-Like quorum sensing systems for development of common therapeutics to treat multiple gram-positive bacterial infections.Sensors (Basel, Switzerland) · 2013Review
- Disrupting the luxS quorum sensing gene does not significantly affect Bacillus anthracis virulence in mice or guinea pigs.Virulence · 2012Article
- Model-driven multi-omic data analysis elucidates metabolic immunomodulators of macrophage activation.Molecular systems biology · 2012Article
- Structural and enzymatic characterization of the lactonase SisLac from Sulfolobus islandicus.PloS one · 2012Article
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
Quorum-sensing (QS), the regulation of bacterial gene expression in response to changes in cell density, involves pathways that synthesize signaling molecules (auto-inducers). The luxS/AI-2-mediated QS system has been identified in both gram-positive and gram-negative bacteria. Bacillus anthracis, the etiological agent of anthrax, possesses genes involved in luxS/AI-2-mediated QS, and deletion of luxS in B. anthracis Sterne strain 34F2 results in inhibition of AI-2 synthesis and a growth defect. In the present study, we created a ΔluxS B. anthracis strain complemented in trans by insertion of a cassette, including luxS and a gene encoding erythromycin resistance, into the truncated plcR regulator locus. The complemented ΔluxS strain has restored AI-2 synthesis and wild-type growth. A B. anthracis microarray study revealed consistent differential gene expression between the wild-type and ΔluxS strain, including downregulation of the B. anthracis S-layer protein gene EA1 and pXO1 virulence genes. These data indicate that B. anthracis may use luxS/AI-2-mediated QS to regulate growth, density-dependent gene expression and virulence factor expression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.