ArticleJournal of neurophysiology2011
The extent and strength of electrical coupling between inferior olivary neurons is heterogeneous.
Article in Journal of neurophysiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed, 94 citations in OpenAlex.
- Defining the electrical synapse.Nature reviews. Neuroscience · 2026Review
- Frequency-dependent coupling in response to oscillatory inputs in minimal networks of electrically coupled nodes: Gap junction networks and spatially extended neurons.Biological cybernetics · 2026Article
- When microscopy and electrophysiology meet connectomics-Steve Massey's contribution to unraveling the structure and function of the rod/cone gap junction.Frontiers in ophthalmology · 2023Review
- Function and Plasticity of Electrical Synapses in the Mammalian Brain: Role of Non-Junctional Mechanisms.Biology · 2022Review
- Designing AAV Vectors for Monitoring the Subtle Calcium Fluctuations of Inferior Olive NetworkFrontiers in cellular neuroscience · 2022Article
- Regulatory Roles of Metabotropic Glutamate Receptors on Synaptic Communication Mediated by Gap Junctions.Neuroscience · 2021Review
- Phosphorylation of Connexin36 near the C-terminus switches binding affinities for PDZ-domain and 14-3-3 proteins in vitro.Scientific reports · 2020Article
- Article
- Molecular and functional architecture of the mouse photoreceptor network.Science advances · 2020Article
- Electrical coupling controls dimensionality and chaotic firing of inferior olive neurons.PLoS computational biology · 2020Article
- Neuronal Glutamatergic Network Electrically Wired with Silent But Activatable Gap Junctions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- De Novo Synthesized Estradiol: A Role in Modulating the Cerebellar Function.International journal of molecular sciences · 2020Review
- Article
- Imaging Subthreshold Voltage Oscillation With Cellular Resolution in the Inferior OliveFrontiers in cellular neuroscience · 2020Article
- Variability and directionality of inferior olive neuron dendrites revealed by detailed 3D characterization of an extensive morphological library.Brain structure & function · 2019Article
- Beyond plasticity: the dynamic impact of electrical synapses on neural circuits.Nature reviews. Neuroscience · 2019Review
- Gap junction plasticity as a mechanism to regulate network-wide oscillations.PLoS computational biology · 2018Article
- Electrical synapses in mammalian CNS: Past eras, present focus and future directions.Biochimica et biophysica acta. Biomembranes · 2018Review
- Electrical Synapses Enhance and Accelerate Interneuron Recruitment in Response to Coincident and Sequential Excitation.Frontiers in cellular neuroscience · 2018Article
- Targeting neuronal gap junctions in mouse retina offers neuroprotection in glaucoma.The Journal of clinical investigation · 2017Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Gap junctions constitute the only form of synaptic communication between neurons in the inferior olive (IO), which gives rise to the climbing fibers innervating the cerebellar cortex. Although its exact functional role remains undetermined, electrical coupling was shown to be necessary for the transient formation of functional compartments of IO neurons and to underlie the precise timing of climbing fibers required for cerebellar learning. So far, most functional considerations assume the existence of a network of permanently and homogeneously coupled IO neurons. Contrasting this notion, our results indicate that coupling within the IO is highly variable. By combining tracer-coupling analysis and paired electrophysiological recordings, we found that individual IO neurons could be coupled to a highly variable number of neighboring neurons. Furthermore, a given neuron could be coupled at remarkably different strengths with each of its partners. Freeze-fracture analysis of IO glomeruli revealed the close proximity of glutamatergic postsynaptic densities to connexin 36-containing gap junctions, at distances comparable to separations between chemical transmitting domains and gap junctions in goldfish mixed contacts, where electrical coupling was shown to be modulated by the activity of glutamatergic synapses. On the basis of structural and molecular similarities with goldfish mixed synapses, we speculate that, rather than being hardwired, variations in coupling could result from glomerulus-specific long-term modulation of gap junctions. This striking heterogeneity of coupling might act to finely influence the synchronization of IO neurons, adding an unexpected degree of complexity to olivary networks.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.