ArticleAmerican journal of respiratory cell and molecular biology2011
Dendritic cell depletion and repopulation in the lung after irradiation and bone marrow transplantation in mice.
Article in American journal of respiratory cell and molecular biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
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- The bone marrow of mouse-rat chimeras contains progenitors of multiple pulmonary cell lineages.Frontiers in cell and developmental biology · 2024Article
- Rate of recipient-derived alveolar macrophage development and major histocompatibility complex cross-decoration after lung transplantation in humans.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2022Article
- Regulation of Immune Responses by Nonhematopoietic Cells in Asthma.Journal of immunology (Baltimore, Md. : 1950) · 2021Review
- Effects of Hematopoietic Cell Transplantation on the Pulmonary Immune Response to Infection.Frontiers in pediatrics · 2021Review
- Role of Environmental Adjuvants in Asthma Development.Current allergy and asthma reports · 2020Review
- Distinct Tlr4-expressing cell compartments control neutrophilic and eosinophilic airway inflammation.Mucosal immunology · 2015Article
- L-plastin is essential for alveolar macrophage production and control of pulmonary pneumococcal infection.Infection and immunity · 2014Article
- Lung irradiation increases mortality after influenza A virus challenge occurring late after exposure.International journal of radiation oncology, biology, physics · 2013Article
- FMS-like tyrosine kinase 3 ligand treatment of mice aggravates acute lung injury in response to Streptococcus pneumoniae: role of pneumolysin.Infection and immunity · 2012Article
- TNF-related apoptosis-inducing ligand (TRAIL) exerts therapeutic efficacy for the treatment of pneumococcal pneumonia in mice.The Journal of experimental medicine · 2012Article
- Cathepsin G and neutrophil elastase play critical and nonredundant roles in lung-protective immunity against Streptococcus pneumoniae in mice.Infection and immunity · 2011Article
- Local delivery of GM-CSF protects mice from lethal pneumococcal pneumonia.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
Dendritic cells (DCs) are essential for innate and adaptive immunity, but are purported to exhibit variable radiosensitivity in response to irradiation in various bone marrow transplantation (BMT) protocols. To address this controversy, we analyzed the magnitude of depletion and repopulation of both lung CD11b(pos) DC and CD103(pos) DC subsets in response to irradiation and BMT in a murine model. In our study, CD45.2(pos) donor bone marrow cells were transplanted into irradiated CD45.1(pos) recipient mice to examine the depletion of recipient DC subsets and the repopulation of donor DC subsets. We observed an apoptosis-mediated and necrosis-mediated depletion (> 90%) of the recipient CD103(pos) DC subset, and only a 50-60% depletion of recipient CD11b(pos) DCs from lung parenchymal tissue on Days 3 and 5, whereas recipient alveolar and lung macrophages were much less radiosensitive, showing an approximately 50% depletion by Days 14-21 after treatment. A repopulation of lung tissue with donor DC subsets had occurred by Days 10 and 28 for CD11b(pos) DCs and CD103(pos) DCs, whereas alveolar and lung macrophages were repopulated by 6 and 10 weeks after treatment. Furthermore, the infection of mice with Streptococcus pneumoniae further accelerated the turnover of lung DCs and lung macrophage subsets. Our data illustrate the vulnerability of lung CD103(pos) DCs and CD11b(pos) DCs to irradiation, and indicate that an accelerated turnover of lung DC subsets occurs, relative to pulmonary and lung macrophages. Our findings may have important implications in the development of adjuvant immune-stimulatory protocols that could reduce the risk of opportunistic infections in patients undergoing BMT.
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