ReviewThe Journal of experimental biology2011
Molecular population genetics and selection in the glycolytic pathway.
Review in The Journal of experimental biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 47 citations in OpenAlex.
- Insect Flight Energetics and the Evolution of Size, Form, and Function.Integrative and comparative biology · 2024Review
- Balanced Polymorphism at theGenes · 2022Article
- Comparison of Gene Expression Between Resistant and Susceptible Families Against VPFrontiers in genetics · 2021Article
- Positive Selection Evidence in Xylose-Related Genes Suggests Methylglyoxal Reductase as a Target for the Improvement of Yeasts' Fermentation in Industry.Genome biology and evolution · 2019Article
- Metabolic Determinants of Enzyme Evolution in a Genome-Scale Bacterial Metabolic Network.Genome biology and evolution · 2018Article
- Adaptations in energy metabolism and gene family expansions revealed by comparative transcriptomics of three Chagas disease triatomine vectors.BMC genomics · 2018Article
- Genomics of parallel adaptation at two timescales in Drosophila.PLoS genetics · 2017Article
- The Relationship between Selection, Network Connectivity, and Regulatory Variation within a Population of Capsella grandiflora.Genome biology and evolution · 2017Article
- New views on the selection acting on genetic polymorphism in central metabolic genes.Annals of the New York Academy of Sciences · 2017Review
- Article
- Substitutions in the Glycogenin-1 Gene Are Associated with the Evolution of Endothermy in Sharks and Tunas.Genome biology and evolution · 2016Article
- Cold adaptation increases rates of nutrient flow and metabolic plasticity during cold exposure in Drosophila melanogaster.Proceedings. Biological sciences · 2016Article
- Metabolic adaptations in a range-expanding arthropod.Ecology and evolution · 2016Article
- Article
- Genetic perturbation of key central metabolic genes extends lifespan in Drosophila and affects response to dietary restriction.Proceedings. Biological sciences · 2015Article
- Global diversity lines - a five-continent reference panel of sequenced Drosophila melanogaster strains.G3 (Bethesda, Md.) · 2015Article
- A small system--high-resolution study of metabolic adaptation in the central metabolic pathway to temperate climates in Drosophila melanogaster.Molecular biology and evolution · 2014Article
- Relationship between gene duplicability and diversifiability in the topology of biochemical networks.BMC genomics · 2014Article
- Positive selection in glycolysis among Australasian stick insects.BMC evolutionary biology · 2013Article
- Nonlinear fitness consequences of variation in expression level of a eukaryotic gene.Molecular biology and evolution · 2013Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
In this review, I discuss the evidence for differential natural selection acting across enzymes in the glycolytic pathway in Drosophila. Across the genome, genes evolve at very different rates and possess markedly varying levels of molecular polymorphism, codon bias and expression variation. Discovering the underlying causes of this variation has been a challenge in evolutionary biology. It has been proposed that both the intrinsic properties of enzymes and their pathway position have direct effects on their molecular evolution, and with the genomic era the study of adaptation has been taken to the level of pathways and networks of genes and their products. Of special interest have been the energy-producing pathways. Using both population genetic and experimental approaches, our laboratory has been engaged in a study of molecular variation across the glycolytic pathway in Drosophila melanogaster and its close relatives. We have observed a pervasive pattern in which genes at the top of the pathway, especially around the intersection at glucose 6-phosphate, show evidence for both contemporary selection, in the form of latitudinal allele clines, and inter-specific selection, in the form of elevated levels of amino acid substitutions between species. To further explore this question, future work will require corroboration in other species, expansion into tangential pathways, and experimental work to better characterize metabolic control through the pathway and to examine the pleiotropic effects of these genes on other traits and fitness components.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.