Evidence map›Paper›PMID 21177919›Full record

ArticleClinical and vaccine immunology : CVI2011

Evaluation of serum bactericidal antibody assays for Haemophilus influenzae serotype a.

Nadine G Rouphael, Sarah Satola, Monica M Farley, Karen Rudolph, Daniel S Schmidt, Patricia Gomez-de-León, John B Robbins, Rachel Schneerson, George M Carlone, Sandra Romero-Steiner

Open access · diamondAbstract readComparative StudyEvaluation Study
In one paragraph

Article in Clinical and vaccine immunology : CVI, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Nadine G RouphaelDivision of Infectious Diseases, Emory University School of Medicine, 69 Jesse Hill Jr. Drive, Atlanta, Georgia 30303, USA.
Sarah Satola
Monica M Farley
Karen Rudolph
Daniel S Schmidt
Patricia Gomez-de-León
John B Robbins
Rachel Schneerson
George M Carlone
Sandra Romero-Steiner
Universidad Nacional Autónoma de México · MXVeterans Health Administration · USCenters for Disease Control and Prevention · USEmory University · USEunice Kennedy Shriver National Institute of Child Health and Human Development · US

Funding

Development of vaccines to bacterial diseases found especially in childrenZIAHD008839 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI ROBBINS, JOHN · 2009 to 2012
$11.7M
Cross Reacting Polysaccharides (H. influenzae types a and b, and B. pumilus)ZIAHD001301 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI SCHNEERSON, RACHEL · 2009 to 2012
$937k
6 · The paper itself

Abstract

Haemophilus influenzae type a (Hia) is an important pathogen for some American Indian, Alaskan native, and Northern Canada aboriginal populations. Assays to measure serum bactericidal activity (SBA) to Hia have not been developed or validated. Here, we describe two methods for the measurement of SBA: SBA with a viability endpoint (CFU counts) and SBA with a fluorometric endpoint using alamarBlue as the metabolic indicator. Both SBA assays measure Hia-specific functional antibody and correlate with anti-Hia IgG enzyme-linked immunosorbent assay (ELISA) concentration of naturally acquired antibodies.

Indexed as

AdultBacteriological TechniquesCanadaColony Count, MicrobialFluorometryHaemophilus InfectionsHaemophilus influenzaeHumansMicrobial ViabilityMiddle AgedOxazinesReproducibility of ResultsSensitivity and SpecificitySerum Bactericidal Antibody AssayXanthenesOxazinesresazurinXanthenes

Identifiers

PMID21177919
PMCPMC3067367
OpenAlexW2118831748

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.