ArticleClinical and vaccine immunology : CVI2011
Internalization of IgG-coated targets results in activation and secretion of soluble CD40 ligand and RANTES by human platelets.
Article in Clinical and vaccine immunology : CVI, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 39 citations in OpenAlex.
- Platelets in infection: intrinsic roles and functional outcomes.Frontiers in immunology · 2025Review
- Review
- Advances in research on the effects of platelet activation in acute lung injury (Review).Biomedical reports · 2022Review
- Platelet and Megakaryocyte Roles in Innate and Adaptive Immunity.Circulation research · 2022Review
- A Champion of Host Defense: A Generic Large-Scale Cause for Platelet Dysfunction and Depletion in Infection.Seminars in thrombosis and hemostasis · 2020Review
- Significant association between high serum CCL5 levels and better disease-free survival of patients with early breast cancer.Cancer science · 2020Article
- Platelets PromoteFrontiers in immunology · 2018Article
- The Non-Hemostatic Aspects of Transfused Platelets.Frontiers in medicine · 2018Review
- Cancer and Thrombosis: The Platelet Perspective.Frontiers in cell and developmental biology · 2016Review
- A novel conditional platelet depletion mouse model reveals the importance of platelets in protection against Staphylococcus aureus bacteremia.Journal of thrombosis and haemostasis : JTH · 2015Article
- Platelets: essential components of the immune system.Current trends in immunology · 2015Article
- Platelets and infections - complex interactions with bacteria.Frontiers in immunology · 2015Review
- Recent Advances in Discovering the Role of CCL5 in Metastatic Breast Cancer.Mini reviews in medicinal chemistry · 2015Review
- Global proteome analysis identifies active immunoproteasome subunits in human platelets.Molecular & cellular proteomics : MCP · 2014Article
- Platelets: at the nexus of antimicrobial defence.Nature reviews. Microbiology · 2014Review
- Correlation between serum RANTES levels and the severity of Parkinson's disease.Oxidative medicine and cellular longevity · 2014Article
- Bench-to-bedside review: Platelets and active immune functions - new clues for immunopathology?Critical care (London, England) · 2013Review
- Anti-CRLF2 Antibody-Armored Biodegradable Nanoparticles for Childhood B-ALL.Particle & particle systems characterization : measurement and description of particle properties and behavior in powders and other disperse systems · 2013Article
- Human platelets efficiently kill IgG-opsonized E. coli.FEMS immunology and medical microbiology · 2012Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Platelets are crucial elements for maintenance of hemostasis. Other functions attributable to platelets are now being appreciated, such as their role in inflammatory reactions and host defense. Platelets have been reported to bind immunological stimuli like IgG complexes, and for nearly 50 years it has been speculated that platelets may participate in immunological reactions. Platelets have been reported to bind and internalize various substances, similar to other leukocytes, such as macrophages and dendritic cells. In the present study, we tested the hypothesis that human platelets can bind and internalize IgG-coated particles, similar to leukocytes. To this end, we observed that interaction with IgG-coated beads resulted in platelet activation (as measured by CD62P expression), internalization of targets, and significant soluble CD40 ligand (sCD40L) and RANTES (regulated upon activation, normal T cell expresses and secreted) secretion. Blocking FcγRIIA with monoclonal antibody (MAb) IV.3 or inhibiting actin remodeling with cytochalasin D inhibited platelet activation, internalization, and cytokine production. These data suggest that platelets are capable of mediating internalization of IgG-coated particles, resulting in platelet activation and release of both sCD40L and RANTES.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.