ArticleJournal of virology2011
Varicella-zoster virus transcriptome in latently infected human ganglia.
Article in Journal of virology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 64 citations in OpenAlex.
- Variable Gene Expression in Human Ganglia Latently Infected with Varicella-Zoster Virus.Viruses · 2022Article
- Recent Issues in Varicella-Zoster Virus Latency.Viruses · 2021Review
- Review
- Review
- Long-read sequencing uncovers a complex transcriptome topology in varicella zoster virus.BMC genomics · 2018Article
- Clinical Features of Varicella-Zoster Virus Infection.Viruses · 2018Review
- Article
- A spliced latency-associated VZV transcript maps antisense to the viral transactivator gene 61.Nature communications · 2018Article
- Adenoviromics: Mining the Human Adenovirus Species D Genome.Frontiers in microbiology · 2018Review
- Transcriptome-wide characterization of human cytomegalovirus in natural infection and experimental latency.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Targeted Genome Sequencing Reveals Varicella-Zoster Virus Open Reading Frame 12 Deletion.Journal of virology · 2017Article
- Inborn errors in RNA polymerase III underlie severe varicella zoster virus infections.The Journal of clinical investigation · 2017Article
- Alphaherpesvirus DNA replication in dissociated human trigeminal ganglia.Journal of neurovirology · 2016Article
- Human Cytomegalovirus Latency: Approaching the Gordian Knot.Annual review of virology · 2016Article
- Issues in the Treatment of Neurological Conditions Caused by Reactivation of Varicella Zoster Virus (VZV).Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2016Review
- Differential regulation of matrix metalloproteinases in varicella zoster virus-infected human brain vascular adventitial fibroblasts.Journal of the neurological sciences · 2015Article
- A comparison of herpes simplex virus type 1 and varicella-zoster virus latency and reactivation.The Journal of general virology · 2015Review
- Burning mouth syndrome due to herpes simplex virus type 1.BMJ case reports · 2015Article
- Rates of vaccine evolution show strong effects of latency: implications for varicella zoster virus epidemiology.Molecular biology and evolution · 2015Article
- Viruses, apoptosis, and neuroinflammation--a double-edged sword.Journal of neurovirology · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
We recently developed a novel multiplex reverse transcription (RT)-PCR assay that allows rapid and sensitive detection of transcripts corresponding to all 68 unique varicella-zoster virus (VZV) open reading frames (ORFs) in only five amplification reactions (M. A. Nagel, D. Gilden, T. Shade, B. Gao, and R. J. Cohrs, J. Virol. Methods 157:62-68, 2009). Herein, we applied multiplex RT-PCR analysis to mRNA extracted from 26 trigeminal ganglia latently infected with VZV and one control trigeminal ganglion negative for VZV DNA that were removed from 14 men and women, 16 to 84 years of age, within 24 h after death. Analysis identified VZV transcripts mapping to VZV ORFs 29, 62, and 63, previously detected and sequence verified; VZV ORFs 4 and 40, previously detected by in situ hybridization; and VZV ORFs 11, 41, 43, 57, and 68, not previously detected. VZV ORF 63 transcripts were the most prevalent. Comparison of the 10 VZV ORFs transcribed during latency to their herpes simplex virus type 1 homologues reveals that the latently transcribed VZV genes encode immediate-early, early, and late transcripts.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.