ArticleThe Journal of pharmacology and experimental therapeutics2011
Pregabalin modulation of neurotransmitter release is mediated by change in intrinsic activation/inactivation properties of ca(v)2.1 calcium channels.
Article in The Journal of pharmacology and experimental therapeutics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 31 citations in OpenAlex.
- Xenon in the treatment of panic disorder: an open label study.Journal of translational medicine · 2017Trial
- Biochemistry and physiology of voltage-gated calcium channel trafficking: a target for gabapentinoid drugs.Open biology · 2025Review
- Seizures as an Adverse Effect of Pregabalin Consumption: A Systematic Review.Addiction & health · 2025Review
- Drug-Induced Stuttering: Occurrence and Possible Pathways.Frontiers in psychiatry · 2021Article
- Bilateral Serous Macular Detachment After Attempted Suicide with Pregabalin.Turkish journal of ophthalmology · 2018Article
- In vivo imaging reveals that pregabalin inhibits cortical spreading depression and propagation to subcortical brain structures.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Calcium channels and synaptic transmission in familial hemiplegic migraine type 1 animal models.Biophysical reviews · 2014Review
- Teratogenic effects of pregabalin in mice.Iranian journal of basic medical sciences · 2013Article
- Disturbance of consciousness and involuntary movements caused by pregabalin.BMJ case reports · 2012Article
- Gabapentin inhibits catecholamine release from adrenal chromaffin cells.Anesthesiology · 2012Article
- Painful diabetic neuropathy is more than pain alone: examining the role of anxiety and depression as mediators and complicators.Current diabetes reports · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
In this work, we studied the effects of the anticonvulsant and analgesic drug pregabalin (PGB) on excitatory postsynaptic currents (EPSCs) at principal neurons of the mouse medial nucleus of the trapezoid body and on presynaptic calcium currents at the calyx of Held. We found that the acute application of PGB reduced the amplitude of EPSCs in a dose-dependent manner with a maximal blocking effect of approximately 30%. A clinical high-concentration dose of PGB (e.g., 500 μM) blocked Ca(v)2.1 channel-mediated currents and decreased their facilitation during a 100-Hz train, without changing their voltage-dependent activation. Furthermore, PGB also removed the inactivation of Ca(v)2.1 channels at a clinically relevant low concentration of 100 μM. These results suggest novel modulatory mechanisms mediated by the acute administration of PGB on fast excitatory synaptic transmission and might contribute to better understanding PGB anticonvulsant/analgesic clinical effects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.