Evidence map›Paper›PMID 21177656›Full record

ArticleNucleic acids research2011

The Gene Expression Barcode: leveraging public data repositories to begin cataloging the human and murine transcriptomes.

Matthew N McCall, Karan Uppal, Harris A Jaffee, Michael J Zilliox, Rafael A Irizarry

Abstract read
In one paragraph

Article in Nucleic acids research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
105citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

105 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. The Impact of Stroma Admixture on Molecular Subtypes and Prognostic Gene Signatures in Serous Ovarian Cancer.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2020
    Pooled it
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  12. A dynamic multi-tissue model to study human metabolism.NPJ systems biology and applications · 2021
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  14. Methods for correcting inference based on outcomes predicted by machine learning.Proceedings of the National Academy of Sciences of the United States of America · 2020
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  16. Cryo-EM structure of rhinovirus C15a bound to its cadherin-related protein 3 receptor.Proceedings of the National Academy of Sciences of the United States of America · 2020
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45 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Matthew N McCallDepartment of Biostatistics, Johns Hopkins University Bloomberg School of Public Health, 615 N Wolfe Street, Baltimore, MD 21205, USA.
Karan Uppal
Harris A Jaffee
Michael J Zilliox
Rafael A Irizarry

Funding

Institute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8M
Preprocessing and Analysis Tools for High-Throughput TechnologiesR01GM083084 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI IRIZARRY, RAFAEL ANGEL · 2007 to 2018
$4.4M
Software for the Statistical Analysis of Microarray Probe Level DataR01RR021967 · NCRR · JOHNS HOPKINS UNIVERSITY · PI IRIZARRY, RAFAEL ANGEL · 2007 to 2011
$1.2M
Predoctoral Biostatistics Training in Genetics/GenomicsT32GM074906 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI IRIZARRY, RAFAEL ANGEL · 2006 to 2010
$905k
Classifying Cancer Biopsies Using a Gene Expression BarcodeF32CA132480 · NCI · EMORY UNIVERSITY · PI ZILLIOX, MICHAEL JOSEPH · 2008 to 2010
$155k
NCI NIH HHS CA132480NCRR NIH HHS R01 RR021967NCRR NIH HHS RR021967NCRR NIH HHS UL1RR025005NIGMS NIH HHS GM083084NIGMS NIH HHS R01 GM083084NIGMS NIH HHS R01GM083084NIGMS NIH HHS T32 GM074906NIGMS NIH HHS T32GM074906
6 · The paper itself

Abstract

Various databases have harnessed the wealth of publicly available microarray data to address biological questions ranging from across-tissue differential expression to homologous gene expression. Despite their practical value, these databases rely on relative measures of expression and are unable to address the most fundamental question--which genes are expressed in a given cell type. The Gene Expression Barcode is the first database to provide reliable absolute measures of expression for most annotated genes for 131 human and 89 mouse tissue types, including diseased tissue. This is made possible by a novel algorithm that leverages information from the GEO and ArrayExpress public repositories to build statistical models that permit converting data from a single microarray into expressed/unexpressed calls for each gene. For selected platforms, users may upload data and obtain results in a matter of seconds. The raw data, curated annotation, and code used to create our resource are also available at http://rafalab.jhsph.edu/barcode.

Indexed as

Databases, GeneticGene Expression ProfilingOligonucleotide Array Sequence AnalysisAnimalsHumansMiceSoftware

Identifiers

PMID21177656
PMCPMC3013751

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.