ArticleNucleic acids research2011
The chromodomains of CHD1 are critical for enzymatic activity but less important for chromatin localization.
Article in Nucleic acids research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 45 citations in OpenAlex.
- A direct interaction between the Chd1 CHCT domain and Rtf1 controls Chd1 distribution and nucleosome positioning on active genes.Nucleic acids research · 2025Article
- Article
- CHD1, a multifaceted epigenetic remodeler in prostate cancer.Frontiers in oncology · 2023Review
- Regulation of sensory perception and motor abilities by brain-specific action of chromatin remodeling factor CHD1.Frontiers in molecular neuroscience · 2022Article
- CHD1 controls H3.3 incorporation in adult brain chromatin to maintain metabolic homeostasis and normal lifespan.Cell reports · 2021Article
- Amyotrophic Lateral Sclerosis Genes inInternational journal of molecular sciences · 2021Review
- CHD1 Loss Alters AR Binding at Lineage-Specific Enhancers and Modulates Distinct Transcriptional Programs to Drive Prostate Tumorigenesis.Cancer cell · 2019Article
- TDP-43 Promotes Neurodegeneration by Impairing Chromatin Remodeling.Current biology : CB · 2017Article
- CHD1 regulates cell fate determination by activation of differentiation-induced genes.Nucleic acids research · 2017Article
- A novel role for the histone acetyltransferase Hat1 in the CENP-A/CID assembly pathway in Drosophila melanogaster.Nucleic acids research · 2016Article
- Impact of the Chromatin Remodeling Factor CHD1 on Gut Microbiome Composition of Drosophila melanogaster.PloS one · 2016Article
- An RNAi-Based Candidate Screen for Modifiers of the CHD1 Chromatin Remodeler and Assembly Factor in Drosophila melanogaster.G3 (Bethesda, Md.) · 2015Article
- Embryonic stem cell differentiation requires full length Chd1.Scientific reports · 2015Article
- Transcription-coupled recruitment of human CHD1 and CHD2 influences chromatin accessibility and histone H3 and H3.3 occupancy at active chromatin regions.Epigenetics & chromatin · 2015Article
- Chromatin dynamics: interplay between remodeling enzymes and histone modifications.Biochimica et biophysica acta · 2014Review
- Balancing chromatin remodeling and histone modifications in transcription.Trends in genetics : TIG · 2013Review
- Nucleosome remodeling and epigenetics.Cold Spring Harbor perspectives in biology · 2013Review
- The Drosophila melanogaster CHD1 chromatin remodeling factor modulates global chromosome structure and counteracts HP1a and H3K9me2.PloS one · 2013Article
- Chromatin remodelers Isw1 and Chd1 maintain chromatin structure during transcription by preventing histone exchange.Nature structural & molecular biology · 2012Article
- Genome-wide studies of the multi-zinc finger Drosophila Suppressor of Hairy-wing protein in the ovary.Nucleic acids research · 2012Article
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
The molecular motor protein CHD1 has been implicated in the regulation of transcription and in the transcription-independent genome-wide incorporation of H3.3 into paternal chromatin in Drosophila melanogaster. A key feature of CHD1 is the presence of two chromodomains, which can bind to histone H3 methylated at lysine 4 and thus might serve to recruit and/or maintain CHD1 at the chromatin. Here, we describe genetic and biochemical approaches to the study of the Drosophila CHD1 chromodomains. We found that overall localization of CHD1 on polytene chromosomes does not appreciably change in chromodomain-mutant flies. In contrast, the chromodomains are important for transcription-independent activities of CHD1 during early embryonic development as well as for transcriptional regulation of several heat shock genes. However, neither CHD1 nor its chromodomains are needed for RNA polymerase II localization and H3K4 methylation but loss of CHD1 decreases transcription-induced histone eviction at the Hsp70 gene in vivo. Chromodomain mutations negatively affect the chromatin assembly activities of CHD1 in vitro, and they appear to be involved in linking the ATP-dependent motor to the chromatin assembly function of CHD1.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.