ArticleLearning & memory (Cold Spring Harbor, N.Y.)2011
A presynaptic role for FMRP during protein synthesis-dependent long-term plasticity in Aplysia.
Article in Learning & memory (Cold Spring Harbor, N.Y.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 28 citations in OpenAlex.
- Proteomics insights into fragile X syndrome: Unraveling molecular mechanisms and therapeutic avenues.Neurobiology of disease · 2024Review
- Axonal and presynaptic FMRP: Localization, signal, and functional implications.Hearing research · 2023Review
- Genetics of glutamate and its receptors in autism spectrum disorder.Molecular psychiatry · 2022Review
- Liquid-Liquid Phase Separation in Physiology and Pathophysiology of the Nervous System.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Review
- Local Translation in Growth Cones and Presynapses, Two Axonal Compartments for Local Neuronal Functions.Biomolecules · 2020Review
- A newRNA (New York, N.Y.) · 2017Article
- Regulation of neuronal gene expression by local axonal translation.Current genetic medicine reports · 2016Article
- Independent role for presynaptic FMRP revealed by an FMR1 missense mutation associated with intellectual disability and seizures.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- N-myristoylation regulates the axonal distribution of the Fragile X-related protein FXR2P.Molecular and cellular neurosciences · 2014Article
- Activity-dependent regulation of release probability at excitatory hippocampal synapses: a crucial role of fragile X mental retardation protein in neurotransmission.The European journal of neuroscience · 2014Article
- FMRP and Ataxin-2 function together in long-term olfactory habituation and neuronal translational control.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- A target cell-specific role for presynaptic Fmr1 in regulating glutamate release onto neocortical fast-spiking inhibitory neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- RNA-binding proteins and translational regulation in axons and growth cones.Frontiers in neuroscience · 2013Article
- Systematic mapping of fragile X granules in the mouse brain reveals a potential role for presynaptic FMRP in sensorimotor functions.The Journal of comparative neurology · 2012Article
- Studies on Aplysia neurons suggest treatments for chronic human disorders.Current biology : CB · 2012Article
- Cytoplasmic RNA-binding proteins and the control of complex brain function.Cold Spring Harbor perspectives in biology · 2012Review
- Pathological plasticity in fragile X syndrome.Neural plasticity · 2012Review
- Defects in translational regulation contributing to human cognitive and behavioral disease.Current opinion in genetics & development · 2011Review
- [Fragile X syndrome and FMR1-dependent diseases - clinical presentation, epidemiology and molecular background].Developmental period medicineReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Loss of the Fragile X mental retardation protein (FMRP) is associated with presumed postsynaptic deficits in mouse models of Fragile X syndrome. However, the possible presynaptic roles of FMRP in learning-related plasticity have received little attention. As a result, the mechanisms whereby FMRP influences synaptic function remain poorly understood. To investigate the cellular locus of the effects of FMRP on synaptic plasticity, we cloned the Aplysia homolog of FMRP and find it to be highly expressed in neurons. By selectively down-regulating FMRP in individual Aplysia neurons at the sensory-to-motor neuron synapse reconstituted in co-cultures, we demonstrate that FMRP functions both pre- and postsynaptically to constrain the expression of long-term synaptic depression induced by repeated pulses of FMRF-amide. In contrast, FMRP has little to no effect on long-term synaptic facilitation induced by repeated pulses of serotonin. Since other components of signaling pathways involved in plasticity appear to be conserved between Aplysia and mammalian neurons, our findings suggest that FMRP can participate in both pre- and postsynaptic regulation of enduring synaptic plasticity that underlies the storage of certain types of long-term memory.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.