ArticleThe Journal of surgical research2011
Tumor location predicts survival in cutaneous head and neck melanoma.
Article in The Journal of surgical research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Use of Ultrasmall Core-Shell Fluorescent Silica Nanoparticles for Image-Guided Sentinel Lymph Node Biopsy in Head and Neck Melanoma: A Nonrandomized Clinical Trial.JAMA network open · 2021Trial
- Prognostic Implications of Primary Site in Cutaneous Head and Neck Melanoma After the Implementation of Sentinel Node Biopsy: A SEER-Based Analysis (2011-2020).Annals of surgical oncology · 2026Article
- Worse prognosis of local and locally advanced head and neck Merkel cell carcinoma: Is it time to change the treatment paradigm?Frontiers in immunology · 2025Article
- Melanoma in a Colombian population: a survival study.Melanoma management · 2024Article
- Scalp Melanoma: A High-Risk Subset of Cutaneous Head and Neck Melanomas with Distinctive Clinicopathological Features.Journal of clinical medicine · 2023Article
- Predicting cutaneous malignant melanoma patients' survival using deep learning: a retrospective cohort study.Journal of cancer research and clinical oncology · 2023Article
- Stage IIA Skin Melanoma Treatment With ECHO-7 Oncolytic Virus Rigvir.The Permanente journal · 2022Article
- A cross-sectional study of clinical, dermoscopic, histopathological, and molecular patterns of scalp melanoma in patients with or without androgenetic alopecia.Scientific reports · 2022Article
- Primary Alopecia Neoplastica: A Novel Case Report and Literature Review.Skin appendage disorders · 2021Article
- Head and neck melanoma: outcome and predictors in a population-based cohort study.Head & face medicine · 2021Article
- Comparing the characteristics and predicting the survival of patients with head and neck melanoma versus body melanoma: a population-based study.BMC cancer · 2021Article
- Incidence of Cutaneous Melanoma of Eyelid Analysis of the Surveillance, Epidemiology, and End Results Database.Ocular oncology and pathology · 2021Article
- Association of Known Melanoma Risk Factors with Primary Melanoma of the Scalp and Neck.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2020Article
- Primary cutaneous melanoma of the scalp: Patterns of clinical, histological and epidemiological characteristics in Brazil.PloS one · 2020Article
- SunSmart Accreditation and Use of a Professional Policy Drafting Service: Both Positively and Independently Associated with High Sun Protective Hat Scores Derived from Primary School Policies.Journal of skin cancer · 2020Article
- Primary Locations of Malignant Melanoma Lesions Depending on Patients’ Gender and AgeAsian Pacific journal of cancer prevention : APJCP · 2017Article
- The prognostic importance of scalp location in primary head and neck melanoma.Journal of surgical oncology · 2017Article
- Variants in autophagy-related genes and clinical characteristics in melanoma: a population-based study.Cancer medicine · 2016Article
- The Prognostic Value of Age, Sex, and Subsite in Cutaneous Head and Neck Melanoma: A Clinical Review of Recent Literature.Iranian journal of cancer prevention · 2016Review
- Regional signals in the planarian body guide stem cell fate in the presence of genomic instability.Development (Cambridge, England) · 2016Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
backgroundPrior studies documented poorer outcomes in patients with cutaneous head and neck melanoma (CHNM) relative to those with melanoma at other sites. We evaluated survival differences attributable to tumor location in patients with CHNM.
methodsWe queried the Surveillance, Epidemiology, and End Results (SEER) database for patients undergoing surgery for CHNM from 1988 to 2006, excluding patients without biopsy-proven diagnoses, those diagnosed at autopsy, and patients with distant metastases. Using the Kaplan-Meier method, we assessed patient, tumor, and treatment-specific factors on overall survival (OS) and melanoma specific survival (MSS). Cox proportional hazards models assessed the role of tumor location (ear, eyelid, face, lip, scalp/neck) on OS and MSS, while controlling for patient age, gender, race, tumor thickness, tumor ulceration, lymph node status, histologic subtype, type of surgery, and use of radiation. Risks of overall and melanoma-specific mortality were reported as hazard ratios (HR) with 95% confidence intervals (CI).
resultsAmong 27,097 patients, 10-y rates of OS and MSS were 56.1% and 84.7%, respectively. On multivariate analysis, scalp/neck primary site was associated with an increased risk of overall (HR 1.20, CI 1.14-1.26; P < 0.001) and melanoma-specific mortality (HR 1.64, CI 1.49-1.80, P < 0.001) relative to melanomas of the face. Tumors of the lip had poorer MSS (HR 1.55; CI 1.05-2.28, P = 0.03) but not OS (HR 1.03, CI 0.80-1.34; P = 0.80).
conclusionsPatients with melanomas of the scalp/neck have poorer OS and MSS and those with lip melanomas have poorer MSS. These anatomic areas should not be overlooked when performing skin examinations.
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