ArticleReproductive biology and endocrinology : RB&E2010
Association of ghrelin and leptin with reproductive hormones in constitutional delay of growth and puberty.
Article in Reproductive biology and endocrinology : RB&E, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 51 citations in OpenAlex.
- Multi-trait GWAS of reaction norm parameters reveals environment-responsive loci influencing reproductive performance in heifers.Journal of animal science and biotechnology · 2026Article
- Unraveling the impact of hyperleptinemia on female reproduction: insights from transgenic pig model.Biological research · 2024Article
- Precocious Puberty Diagnoses Spike, COVID-19 Pandemic, and Body Mass Index: Findings From a 4-year Study.Journal of the Endocrine Society · 2023Article
- Is blue light exposure a cause of precocious puberty in male rats?Frontiers in endocrinology · 2023Article
- Leptin, ghrelin, nesfatin-1, and orexin-A plasma levels in girls with premature thelarche.Journal of endocrinological investigation · 2022Article
- Differences in Puberty of Girls before and during the COVID-19 Pandemic.International journal of environmental research and public health · 2022Article
- "Sibling" battle or harmony: crosstalk between nesfatin-1 and ghrelin.Cellular and molecular life sciences : CMLS · 2022Review
- Delayed body development with reduced triglycerides levels in leptin transgenic pigs.Transgenic research · 2022Article
- Difference of Precocious Puberty Between Before and During the COVID-19 Pandemic: A Cross-Sectional Study Among Shanghai School-Aged Girls.Frontiers in endocrinology · 2022Article
- A potential role for the adrenal gland in autism.Scientific reports · 2021Article
- Luteinizing Hormone Secretion during Gonadotropin-Releasing Hormone Stimulation Tests in Obese Girls with Central Precocious Puberty.Journal of clinical research in pediatric endocrinology · 2016Article
- Aging influences steroid hormone release by mink ovaries and their response to leptin and IGF-I.Biology open · 2016Article
- The Changes of Serum Leptin and Kisspeptin Levels in Chinese Children and Adolescents in Different Pubertal Stages.International journal of endocrinology · 2016Article
- Ultrastructural study of spermatogenesis in KSR2 deficient mice.Transgenic research · 2015Article
- The gonadal function in obese adolescents: review.Journal of endocrinological investigation · 2014Review
- Metabolic influences on neuroendocrine regulation of reproduction.Current opinion in endocrinology, diabetes, and obesity · 2013Review
- Leptin signaling and circuits in puberty and fertility.Cellular and molecular life sciences : CMLS · 2013Review
- Ghrelin and leptin modulate the feeding behaviour of the hawksbill turtle Eretmochelys imbricata during nesting season.Conservation physiology · 2013Article
- Leptin levels in children and adults with classic galactosaemia.JIMD reports · 2013Article
- Correlation of body mass index to Ghrelin and IGF-1 among children with short stature.Jornal de pediatriaArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundConstitutional delay of growth and puberty (CDGP) is a variation of the onset and timing of pubertal development without a defined endocrine abnormality. Recently published studies indicate that leptin and ghrelin play a role in puberty initiation and progress. They have been implicated in regulation of GnRH secretion, with ghrelin having inhibitory and leptin, facilitatory effects. We hypothesized that elevated ghrelin and reduced leptin concentrations could be implicated in altering the tempo of puberty in adolescents with CDGP. So in the current study we evaluate variations in leptin and ghrelin levels in adolescent boys with CDGP, the relationships between both hormones and reproductive hormones including LH, FSH and testosterone were also evaluated.
methodsThe study enrolled 23 adolescent boys with CDGP and 20 healthy controls matched for age and sex. Weight, height, BMI, testicular volume, bone age, bone age delay, serum FSH, LH, testosterone, leptin and ghrelin were assessed.
resultsAdolescent boys with CDGP had significantly lower leptin and higher ghrelin than normal controls. Leptin was positively correlated with BMI, bone age, testicular volume, FSH, LH and testosterone and negatively correlated with delayed bone age and ghrelin. Ghrelin was negatively correlated with BMI, bone age, testicular volume, FSH, LH and testosterone. With multiple regression analysis BMI, FSH, LH, testosterone and ghrelin remained independently correlated with leptin while BMI, LH and testosterone remained independently correlated with ghrelin.
conclusionElevated serum ghrelin and decreased leptin concentrations and their associations with reproductive hormones may explain the sexual immaturity in adolescent boys with CDGP.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.