Evidence map›Paper›PMID 21176031›Full record

ArticleBipolar disorders2010

Social competence and observer-rated social functioning in bipolar disorder.

Colin A Depp, Brent T Mausbach, Philip D Harvey, Christopher R Bowie, Paula S Wolyniec, Mary H Thornquist, James R Luke, John A McGrath, Ann E Pulver, Thomas L Patterson

Open access · greenAbstract read
In one paragraph

Article in Bipolar disorders, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 5 pooled it
2.1field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 5 syntheses or guidelines pooled it, 53 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Aging and Engaging: A Pilot Randomized Controlled Trial of an Online Conversational Skills Coach for Older Adults.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2021
    Trial
  7. Trial
  8. Neuromodulation of swarming behavior inProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  9. Article
  10. Article
  11. Neuromodulation of Swarming Behavior inbioRxiv : the preprint server for biology · 2025
    Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Colin A DeppStein Institute for Research on Aging, Department of Psychiatry, University of California-San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0664, USA. cdepp@ucsd.edu
Brent T Mausbach
Philip D Harvey
Christopher R Bowie
Paula S Wolyniec
Mary H Thornquist
James R Luke
John A McGrath
Ann E Pulver
Thomas L Patterson
Johns Hopkins University · USUniversity of California, San Diego · USJohns Hopkins Medicine · USQueen's University · CAUniversity of Miami · US

Funding

Chronic Psychiatric Disorders: Linking Genes to Functional DisabilityR01MH079784 · NIMH · JOHNS HOPKINS UNIVERSITY · PI PULVER, ANN E · 2007 to 2011
$3.8M
Validating Assessments of Real-World OutcomeR01MH078737 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PATTERSON, THOMAS L. · 2007 to 2011
$1.7M
Validation of Measures of real-world outcomeR01MH078775 · NIMH · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI HARVEY, PHILIP D. · 2007 to 2011
$1.7M
A Medication Adherence Intervention for Older Adults with Bipolar DisorderK23MH077225 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DEPP, COLIN A. · 2007 to 2011
$763k
Development of a Personalized Real-Time Intervention for Bipolar DisorderR34MH091260 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DEPP, COLIN A. · 2010 to 2012
$691k
NIMH NIH HHS K23 MH077225NIMH NIH HHS K23MH077225NIMH NIH HHS R01 MH078737NIMH NIH HHS R01MH078737NIMH NIH HHS R01 MH078775NIMH NIH HHS R01MH078775NIMH NIH HHS R01 MH079784NIMH NIH HHS R01MH079784NIMH NIH HHS R34 MH091260
6 · The paper itself

Abstract

objectiveImpairment in social functioning appears to be common in bipolar disorder, although estimates have been derived largely from self-report measures. We examined performance-based and observer-based ratings of social competence and functioning and assessed the contribution of symptoms and neurocognitive ability to social functioning in bipolar disorder.

methodsIn this cross-sectional study, 164 subjects with bipolar disorder were administered the performance-based Social Skills Performance Assessment (SSPA), rated by an informant on the Specific Level of Functioning (SLOF)-Interpersonal subscale, received clinical ratings of depression and manic symptoms, and performed neurocognitive tests. We assessed the proportion of patients exhibiting social deficits and examined the associations between composite measures of neurocognitive ability, depression and manic symptoms, and SSPA scores with informant-rated, real-world social functioning.

resultsMean age of the sample was 47.6 years (SD = 14.1). Subjects were experiencing, on average, mild levels of depression and minimal manic symptoms. A total of 29% exhibited norm-referenced impairment on the SSPA, and 64% registered at least one impairment on SLOF items; unemployed subjects had lower SSPA and SLOF ratings. Neurocognitive performance correlated with both performance-based and observer-rated social functioning, whereas depressive and manic symptoms correlated only with observer-rated social impairments. In multivariate models, depression was the most potent association with social functioning, and impairment in social competence (i.e., capacity) increased the strength of the relationships between depression and neurocognitive impairment and social functioning (i.e., real-world functioning).

conclusionsOur study confirmed the negative relationship of bipolar depression with social functioning. A subgroup of outpatients with bipolar disorder has impaired social competence, which, when present, worsened the impact of depression and cognitive impairment on social functioning.

Indexed as

Social BehaviorAdaptation, PsychologicalAdultBipolar DisorderCognitionCross-Sectional StudiesDepressionEmploymentFemaleHumansMaleMiddle AgedPsychiatric Status Rating ScalesSurveys and Questionnaires

Identifiers

PMID21176031
PMCPMC3639014
OpenAlexW1936945751

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.