ReviewThe Biochemical journal2011
The myotubularin family of lipid phosphatases in disease and in spermatogenesis.
Review in The Biochemical journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 46 citations in OpenAlex.
- MTMR7 regulates human spermatogonial stem cells proliferation and migration via targeting FLNB.PloS one · 2025Article
- Disruption of CFAP418 interaction with lipids causes widespread abnormal membrane-associated cellular processes in retinal degenerations.JCI insight · 2024Article
- An integrative analysis reveals the prognostic value and potential functions of MTMR2 in hepatocellular carcinoma.Scientific reports · 2023Article
- Article
- The Small-Molecule Enhancers of Autophagy AUTEN-67 and -99 Delay Ageing inInternational journal of molecular sciences · 2023Article
- Sortilin knock-down alters the expression and distribution of cathepsin D and prosaposin and up-regulates the cation-dependent mannose-6-phosphate receptor in rat epididymal cells.Scientific reports · 2023Article
- Myotubularin-related phosphatase 5 is a critical determinant of autophagy in neurons.Current biology : CB · 2022Article
- Genomic architecture of phenotypic extremes in a wild cervid.BMC genomics · 2022Article
- A mutation in MTM1 causes X-Linked myotubular myopathy in Boykin spaniels.Neuromuscular disorders : NMD · 2020Article
- Genome-Wide Association Study Reveals Candidate Genes for Litter Size Traits in Pelibuey Sheep.Animals : an open access journal from MDPI · 2020Article
- MTMR2 promotes invasion and metastasis of gastric cancer via inactivating IFNγ/STAT1 signaling.Journal of experimental & clinical cancer research : CR · 2019Article
- Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family.Molecular & cellular proteomics : MCP · 2016Article
- Skeletal Muscle Pathology in X-Linked Myotubular Myopathy: Review With Cross-Species Comparisons.Journal of neuropathology and experimental neurology · 2016Review
- Breast cancer resistance protein regulates apical ectoplasmic specialization dynamics stage specifically in the rat testis.American journal of physiology. Endocrinology and metabolism · 2013Article
- Protein tyrosine phosphatases--from housekeeping enzymes to master regulators of signal transduction.The FEBS journal · 2013Review
- Biochemistry and structure of phosphoinositide phosphatases.BMB reports · 2013Review
- Bell-shaped and ultrasensitive dose-response in phosphorylation-dephosphorylation cycles: the role of kinase-phosphatase complex formation.BMC systems biology · 2012Article
- The blood-testis barrier and its implications for male contraception.Pharmacological reviews · 2012Review
- The role of myotubularin-related phosphatases in the control of autophagy and programmed cell death.Advances in biological regulation · 2012Review
- Polarity proteins and actin regulatory proteins are unlikely partners that regulate cell adhesion in the seminiferous epithelium during spermatogenesis.Histology and histopathology · 2011Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The MTM (myotubularin)/MTMR (myotubularin-related) protein family is comprised of 15 lipid phosphatases, of which nine members are catalytically active. MTMs are known to play a fundamental role in human physiology as gene mutations can give rise to X-linked myotubular myopathy or Charcot-Marie-Tooth disease, which manifest in skeletal muscle or in peripheral neurons respectively. Interestingly, studies have shown MTMR2 and MTMR5, two MTM family members, to be highly expressed in the testis, particularly in Sertoli and germ cells, and knockout of either gene resulted in spermatogenic defects. Other studies have shown that MTMR2 functions in endocytosis and membrane trafficking. In the testis, MTMR2 interacts and co-localizes with c-Src/phospho-Src-(Tyr⁴¹⁶), a non-receptor protein tyrosine kinase that regulates the phosphorylation state of proteins at the apical ES (ectoplasmic specialization), a unique type of cell junction found between Sertoli cells and elongating/elongated spermatids. In the present review, we highlight recent findings that have made a significant impact on our understanding of this protein family in normal cell function and in disease, with the emphasis on the role of MTMs and MTMRs in spermatogenesis. We also describe a working model to explain how MTMR2 interacts with other proteins such as c-Src, dynamin 2, EPS8 (growth factor receptor pathway substrate 8) and ARP2/3 (actin-related protein 2/3) at the apical ES and the apical TBC (tubulobulbar complex; tubular-like invaginations that function in the disassembly of the apical ES and in the recycling of its components) to regulate spermiation at late stage VIII of the seminiferous epithelial cycle.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.