ReviewPharmacogenomics2011
How can we identify parasite genes that underlie antimalarial drug resistance?
Review in Pharmacogenomics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed.
- Revolution in malaria detection: unveiling current breakthroughs and tomorrow's possibilities in biomarker innovation.Annals of medicine and surgery (2012) · 2024Review
- Malaria Genomics, Vaccine Development, and Microbiome.Pathogens (Basel, Switzerland) · 2023Review
- Genetic mapping of determinants in drug resistance, virulence, disease susceptibility, and interaction of host-rodent malaria parasites.Parasitology international · 2022Review
- Optimizing bulk segregant analysis of drug resistance usingiScience · 2022Article
- Predicting the genomic resolution of bulk segregant analysis.G3 (Bethesda, Md.) · 2022Article
- Extrachromosomal DNA amplicons in antimalarial-resistant Plasmodium falciparum.Molecular microbiology · 2021Article
- Genetic diversity of next generation antimalarial targets: A baseline for drug resistance surveillance programmes.International journal for parasitology. Drugs and drug resistance · 2017Article
- Population Parameters Underlying an Ongoing Soft Sweep in Southeast Asian Malaria Parasites.Molecular biology and evolution · 2017Article
- Independent origins of loss-of-function mutations conferring oxamniquine resistance in a Brazilian schistosome population.International journal for parasitology · 2016Article
- DNA damage regulation and its role in drug-related phenotypes in the malaria parasites.Scientific reports · 2016Article
- The population genetics of drug resistance evolution in natural populations of viral, bacterial and eukaryotic pathogens.Molecular ecology · 2016Review
- How Robust Are Malaria Parasite Clearance Rates as Indicators of Drug Effectiveness and Resistance?Antimicrobial agents and chemotherapy · 2015Article
- Measuring windows of selection for anti-malarial drug treatments.Malaria journal · 2015Article
- Advances in genetics and genomics: use and limitations in achieving malaria elimination goals.Pathogens and global health · 2015Review
- Understanding genetic variation in in vivo tolerance to artesunate: implications for treatment efficacy and resistance monitoring.Evolutionary applications · 2015Article
- Recent advances in candidate-gene and whole-genome approaches to the discovery of anthelmintic resistance markers and the description of drug/receptor interactions.International journal for parasitology. Drugs and drug resistance · 2014Review
- In vitro resistance selections for Plasmodium falciparum dihydroorotate dehydrogenase inhibitors give mutants with multiple point mutations in the drug-binding site and altered growth.The Journal of biological chemistry · 2014Article
- Use of proscribed chloroquine is associated with an increased risk of pfcrt T76 mutation in some parts of Ghana.Malaria journal · 2014Article
- Development of potent autophagy inhibitors that sensitize oncogenic BRAF V600E mutant melanoma tumor cells to vemurafenib.Autophagy · 2014Article
- Screening and hit evaluation of a chemical library against blood-stage Plasmodium falciparum.Malaria journal · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
This article outlines genome-scale approaches that can be used to identify mutations in malaria (Plasmodium) parasites that underlie drug resistance and contribute to treatment failure. These approaches include genetic mapping by linkage or genome-wide association studies, drug selection and characterization of resistant mutants, and the identification of genome regions under strong recent selection. While these genomic approaches can identify candidate resistance loci, genetic manipulation is needed to demonstrate causality. We therefore also describe the growing arsenal of available transfection approaches for direct incrimination of mutations suspected to play a role in resistance. Our intention is both to review past progress and highlight promising approaches for future investigations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.