ArticleOrganic letters2011
Histone deacetylase inhibitors as a tool to up-regulate new fungal biosynthetic products: isolation of EGM-556, a cyclodepsipeptide, from Microascus sp.
Article in Organic letters, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Elucidation of novel turnagainolides and their biosynthetic gene cluster inApplied and environmental microbiology · 2025Article
- Activation of Cryptic Secondary Metabolite Biosynthesis in Tobacco BY-2 Suspension Cells by Epigenetic Modifiers.Applied biochemistry and biotechnology · 2025Article
- Recent Advances in Search of Bioactive Secondary Metabolites from Fungi Triggered by Chemical Epigenetic Modifiers.Journal of fungi (Basel, Switzerland) · 2023Review
- Cryptic Metabolites from Marine-Derived Microorganisms Using OSMAC and Epigenetic Approaches.Marine drugs · 2022Review
- Article
- Secondary metabolites from hypocrealean entomopathogenic fungi: novel bioactive compounds.Natural product reports · 2020Review
- Chromatin-dependent regulation of secondary metabolite biosynthesis in fungi: is the picture complete?FEMS microbiology reviews · 2019Review
- On top of biosynthetic gene clusters: How epigenetic machinery influences secondary metabolism in fungi.Biotechnology advances · 2019Review
- Exploring Structural Diversity of Microbe Secondary Metabolites Using OSMAC Strategy: A Literature Review.Frontiers in microbiology · 2019Review
- Co-cultivation With 5-Azacytidine Induced New Metabolites From the Zoanthid-Derived FungusFrontiers in chemistry · 2019Article
- Modulation of polyketide biosynthetic pathway of the endophytic fungus,Phytochemistry letters · 2018Article
- Hybrid Transcription Factor Engineering Activates the Silent Secondary Metabolite Gene Cluster for (+)-Asperlin in Aspergillus nidulans.ACS chemical biology · 2018Article
- Extending the "One Strain Many Compounds" (OSMAC) Principle to Marine Microorganisms.Marine drugs · 2018Review
- Structural Diversity and Biological Activities of Cyclic Depsipeptides from Fungi.Molecules (Basel, Switzerland) · 2018Review
- An epigenetic modifier induces production of (10'S)-verruculide B, an inhibitor of protein tyrosine phosphatases by Phoma sp. nov. LG0217, a fungal endophyte of Parkinsonia microphylla.Bioorganic & medicinal chemistry · 2017Article
- Multicomponent Analysis of the Differential Induction of Secondary Metabolite Profiles in Fungal Endophytes.Molecules (Basel, Switzerland) · 2016Article
- Chlorinated polyketide obtained from a Daldinia sp. treated with the epigenetic modifier suberoylanilide hydroxamic acid.Journal of natural products · 2014Article
- Co-cultivation--a powerful emerging tool for enhancing the chemical diversity of microorganisms.Marine drugs · 2014Review
- Epigenetic Manipulation of a Filamentous Fungus by the Proteasome-Inhibitor Bortezomib Induces the Production of an Additional Secondary Metabolite.RSC advances · 2014Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The histone deacetylase (HDAC) inhibitor suberoylanilide hydroxamic acid (SAHA) was used to turn on the biosynthesis of EGM-556, a new cyclodepsipeptide of hybrid biosynthetic origin, isolated from the Floridian marine sediment-derived fungus Microascus sp. The absolute configurations of three chiral centers were determined by Marfey's derivatization. EGM-556 represents one of the few examples in which silent biosynthetic genes, encoding a new secondary metabolite, were activated by means of epigenetic manipulation of the fungal metabolome.
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