SynthesisJournal of cancer research and clinical oncology2011
Meta-analysis of the association between VEGF-634 G>C and risk of malignancy based on 23 case-control studies.
Synthesis in Journal of cancer research and clinical oncology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 10 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 10 syntheses or guidelines pooled it.
- Systematic Review and Meta-Analysis of the Relationship between EPHX1 Polymorphisms and the Risk of Head and Neck Cancer.PloS one · 2015Pooled it
- Vascular endothelial growth factor gene polymorphism (-634G/C) and breast cancer risk.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Pooled it
- Ethnic background and genetic variation in the evaluation of cancer risk: a systematic review.PloS one · 2014Pooled it
- Vascular endothelial growth factor (VEGF) gene polymorphisms and risk of head and neck cancer: a meta-analysis involving 2,444 individuals.Molecular biology reports · 2013Pooled it
- Adiponectin (ADIPOQ) rs2241766 G/T polymorphism is associated with risk of cancer: evidence from a meta-analysis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2013Pooled it
- Helicobacter pylori infection contributes to high risk of ischemic stroke: evidence from a meta-analysis.Journal of neurology · 2012Pooled it
- Meta-analyses of the associations between four common TGF-β1 genetic polymorphisms and risk of colorectal tumor.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2012Pooled it
- Polymorphism of vascular endothelial growth factor -1154G>A (rs1570360) with cancer risk: a meta-analysis of 16 case-control studies.Molecular biology reports · 2012Pooled it
- System review and metaanalysis of the relationships between five metabolic gene polymorphisms and colorectal adenoma risk.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2012Pooled it
- Systematic review and meta-analysis of the relationship between EPHX1 polymorphisms and colorectal cancer risk.PloS one · 2012Pooled it
- Association of VEGFA polymorphisms with the risk of oesophageal cancer in Punjab, India: A case-control study.The Indian journal of medical research · 2024Article
- Difference of polymorphism VEGF-gene rs699947 in Indonesian chronic liver disease population.PloS one · 2017Article
- Polymorphisms of interleukin-10 genes on the risk of ischemic stroke in a meta-analysis.International journal of clinical and experimental medicine · 2015Article
- Positive association of the vascular endothelial growth factor-A +405 GG genotype and poor survival in stage I-II gastric cancer in the Northern Chinese population.Molecular biology reports · 2013Article
- The role of vascular endothelial growth factor a polymorphisms in breast cancer.International journal of molecular sciences · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe association between polymorphism of vascular endothelial growth factor (VEGF)-634 G>C and malignancy risk has been widely studied, and no conclusive result was available up to now.
methodsTwenty-three case-control studies with 21,917 individuals were included in this meta-analysis through searching the databases of Medline, Embase, and CNKI (up to October 1st, 2010). The odds ratio (OR) and 95% confidence interval (95%CI) were used to investigate the strength of the association.
resultsOverall, the pooled analysis showed that there was no association between VEGF-634 G>C and risk of malignancy, and the ORs (95%CIs) were 0.98 (0.85-1.12) for GG versus CC, 1.03 (0.90-1.17) for GC versus CC, 1.00 (0.89-1.13) for G carrier versus CC, and 1.08 (0.94-1.23) for C carrier versus GG. Subgroup analyses according to ethnicity, source of control, type of cancer, and sample size were also performed, and results indicated that VEGF-634 G>C was not associated with risk of malignancy for neither Asians [1.06 (0.81-1.38) for GG vs. CC and 1.08 (0.84-1.39) for GC vs. CC] nor Caucasians [0.93 (0.83-1.05) for GG vs. CC and 0.98 (0.87-1.10) for GC vs. CC]. It was also not associated with risk of breast cancer [0.95 (0.81-1.12) for GG vs. CC], gastric cancer [0.93 (0.47-1.84) for GG vs. CC], and colorectal cancer [1.17 (0.93-1.47) for GG vs. CC].
conclusionsThis meta-analysis suggests that VEGF-634 G>C may be not associated with risk of malignancy. More studies with larger sample size were needed to provide more precise evidence.
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