ArticleNature cell biology2011
Chaperoning the SNAREs: a role in preventing neurodegeneration?
Article in Nature cell biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed.
- A Deep Learning and PSSM Profile Approach for Accurate SNARE Protein Prediction.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Identifying SNARE Proteins Using an Alignment-Free Method Based on Multiscan Convolutional Neural Network and PSSM Profiles.Journal of chemical information and modeling · 2022Article
- CSPα in neurodegenerative diseases.Frontiers in aging neuroscience · 2022Review
- Synaptic Function and Dysfunction in Lysosomal Storage Diseases.Frontiers in cellular neuroscience · 2021Article
- Neuropathophysiology of Lysosomal Storage Diseases: Synaptic Dysfunction as a Starting Point for Disease Progression.Journal of clinical medicine · 2020Review
- AeLife · 2019Article
- SNAP25 Gene Polymorphisms Protect Against Parkinson's Disease and Modulate Disease Severity in Patients.Molecular neurobiology · 2019Article
- Is Parkinson's disease a lysosomal disorder?Brain : a journal of neurology · 2018Article
- Proteome Analysis of Potential Synaptic Vesicle Cycle Biomarkers in the Cerebrospinal Fluid of Patients with Sporadic Creutzfeldt-Jakob Disease.Molecular neurobiology · 2017Article
- Gene expression profiling in the human alcoholic brain.Neuropharmacology · 2017Review
- Lysosomal dysfunction disrupts presynaptic maintenance and restoration of presynaptic function prevents neurodegeneration in lysosomal storage diseases.EMBO molecular medicine · 2017Article
- Phosphorylation of Cysteine String Protein Triggers a Major Conformational Switch.Structure (London, England : 1993) · 2016Article
- Glial expression of Swiss cheese (SWS), the Drosophila orthologue of neuropathy target esterase (NTE), is required for neuronal ensheathment and function.Disease models & mechanisms · 2016Article
- Ethosuximide ameliorates neurodegenerative disease phenotypes by modulating DAF-16/FOXO target gene expression.Molecular neurodegeneration · 2015Article
- Leveraging existing data sets to generate new insights into Alzheimer's disease biology in specific patient subsets.Scientific reports · 2015Article
- Expression profile of a Caenorhabditis elegans model of adult neuronal ceroid lipofuscinosis reveals down regulation of ubiquitin E3 ligase components.Scientific reports · 2015Article
- SNAP-25 is abundantly expressed in enteric neuronal networks and upregulated by the neurotrophic factor GDNF.Histochemistry and cell biology · 2015Article
- Cysteine string protein (CSP) and its role in preventing neurodegeneration.Seminars in cell & developmental biology · 2015Review
- The Gos28 SNARE protein mediates intra-Golgi transport of rhodopsin and is required for photoreceptor survival.The Journal of biological chemistry · 2014Article
- Caenorhabditis elegans dnj-14, the orthologue of the DNAJC5 gene mutated in adult onset neuronal ceroid lipofuscinosis, provides a new platform for neuroprotective drug screening and identifies a SIR-2.1-independent action of resveratrol.Human molecular genetics · 2014Article
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2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite their potential importance as therapeutic targets, the initial events in neurodegenerative diseases are poorly understood. Emerging evidence suggests that presynaptic dysfunction might be an early event in these pathologies, and three papers now link dysregulation of SNAREprotein levels and function caused by the absence of synuclein or cysteine string protein (CSP) to activity-dependent neurodegeneration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.