Evidence map›Paper›PMID 21173775›Full record

ReviewNature reviews. Genetics2011

Elucidating the inosinome: global approaches to adenosine-to-inosine RNA editing.

Bjorn-Erik Wulff, Masayuki Sakurai, Kazuko Nishikura

Abstract readReview
In one paragraph

Review in Nature reviews. Genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Temperature-Dependent tRNA Modifications in Bacillales.International journal of molecular sciences · 2024
    Article
  10. Review
  11. Review
  12. Article
  13. Detection technologies for RNA modifications.Experimental & molecular medicine · 2022
    Review
  14. Review
  15. Article
  16. Crucial Roles of miR-625 in Human Cancer.Frontiers in medicine · 2022
    Review
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Bjorn-Erik WulffThe Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania 19104, USA. wulff@sas.upenn.edu
Masayuki Sakurai
Kazuko Nishikura

Funding

STRUCTURE AND FUNCTION OF DSRNA ADENOSINE DEAMINASER01GM040536 · NIGMS · WISTAR INSTITUTE · PI NISHIKURA, KAZUKO · 1991 to 2021
$8.1M
Control of Cardiogenesis by microRNA EditingRC1HL099342 · NHLBI · WISTAR INSTITUTE · PI NISHIKURA, KAZUKO · 2009 to 2010
$990k
NHLBI NIH HHS RC1 HL099342NIGMS NIH HHS R01 GM040536
6 · The paper itself

Abstract

Catalysed by members of the adenosine deaminase acting on RNA (ADAR) family of enzymes, adenosine-to-inosine (A-to-I) editing converts adenosines in RNA molecules to inosines, which are functionally equivalent to guanosines. Recently, global approaches to studying this widely conserved phenomenon have emerged. The use of bioinformatics, high-throughput sequencing and other approaches has increased the number of known editing sites by several orders of magnitude, and we now have a greater understanding of the control and the biological significance of editing. This Progress article reviews some of these recent global studies and their results.

Indexed as

RNA EditingAdenosineAnimalsHumansInosineNucleic Acid ConformationRNAAdenosineInosineRNA

Identifiers

PMID21173775
PMCPMC3075016

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.