Evidence map›Paper›PMID 21173278›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2011

Mechanism of inactivation of influenza viruses by immobilized hydrophobic polycations.

Bryan B Hsu, Sze Yinn Wong, Paula T Hammond, Jianzhu Chen, Alexander M Klibanov

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

  1. Article
  2. Effect of DMPEI coating against biofilm formation on PVC catheter surface.World journal of microbiology & biotechnology · 2023
    Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Passive antifouling and active self-disinfecting antiviral surfaces.Chemical engineering journal (Lausanne, Switzerland : 1996) · 2022
    Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Review
  13. Review
  14. Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Future antiviral polymers by plasma processing.Progress in polymer science · 2021
    Review
  20. Designing antiviral surfaces to suppress the spread of COVID-19.Physics of fluids (Woodbury, N.Y. : 1994) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Bryan B HsuDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Sze Yinn Wong
Paula T Hammond
Jianzhu Chen
Alexander M Klibanov

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

N,N-dodecyl,methyl-polyethylenimine coatings applied to solid surfaces have been shown by us to disinfect aqueous solutions of influenza viruses. Herein we elucidate the mechanism of this phenomenon. Infectivity-, protein-, RNA-, and scanning electron microscopy-based experiments reveal that, upon contact with the hydrophobic polycationic coating, influenza viruses (including pathogenic human and avian, both wild-type and drug-resistant, strains) irreversibly adhere to it, followed by structural damage and inactivation; subsequently, viral RNA is released into solution, while proteins remain adsorbed.

Indexed as

Base SequenceDisinfectionElectrophoresis, Polyacrylamide GelEnzyme-Linked Immunosorbent AssayHydrophobic and Hydrophilic InteractionsInfluenza A Virus, H1N1 SubtypeMicroscopy, Electron, ScanningMolecular Sequence DataPolyaminesPolyelectrolytesPolyethyleneimineReverse Transcriptase Polymerase Chain ReactionRNA, ViralSequence Analysis, DNAVirus InactivationN,N-dodecyl,methyl-polyethyleniminePolyaminesPolyelectrolytesPolyethyleneimineRNA, Viral

Identifiers

PMID21173278
PMCPMC3017173

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.