ArticleAnesthesia and analgesia2011
Intraoperative methadone: rediscovery, reappraisal, and reinvigoration?
5 registry-linked trialsAbstract readCommentEditorial
In one paragraph
Article in Anesthesia and analgesia, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 50 papers.
0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Does Intraoperative Methadone Prevent Postoperative Pain in Bariatric Surgery?
NCT06387303 early_phase1recruitingnot on this mapstarted 2024, after this paper: background citation
Pain Control and Quality of Recovery After Intravenous Methadone Versus Intrathecal Morphine in Major Abdominal Surgery
NCT06810336 early_phase1recruitingnot on this mapstarted 2025, after this paper: background citation
Pain Control and Quality of Recovery After Intravenous Methadone Versus Intravenous Remifentanil in Craniotomy Surgery
Methadone to Reduce Chronic Opioid Use After Major Spine Surgery: The MEND Pilot Feasibility Study
A Prospective, Randomized Trial Utilizing Methadone in the Management of Post-Operative Pain in Total Knee Replacement
Who cites it
50 citing papers in PubMed.
- Single-dose Intraoperative Methadone for Pain Management in Pediatric Tonsillectomy: A Randomized Double-blind Clinical Trial.Anesthesiology · 2024Trial
- Intraoperative Methadone in Next-day Discharge Outpatient Surgery: A Randomized, Double-blinded, Dose-finding Pilot Study.Anesthesiology · 2023Trial
- Morphine and Hydromorphone Effects, Side Effects, and Variability: A Crossover Study in Human Volunteers.Anesthesiology · 2023Trial
- Intraoperative Methadone in Same-Day Ambulatory Surgery: A Randomized, Double-Blinded, Dose-Finding Pilot Study.Anesthesia and analgesia · 2019Trial
- Pharmacokinetics and analgesic effects of methadone in children and adults with sickle cell disease.Pediatric blood & cancer · 2016Trial
- Methadone Pharmacogenetics: CYP2B6 Polymorphisms Determine Plasma Concentrations, Clearance, and Metabolism.Anesthesiology · 2015Trial
- [Comparison of postoperative analgesia with methadone versus morphine in cardiac surgery].Brazilian journal of anesthesiology (Elsevier)Trial
- Single-dose intraoperative methadone and QTc interval: a prospective observational cohort investigation.British journal of anaesthesia · 2026Observational
- Improving postoperative pain management after minimally invasive coronary surgery using methadone analgesia and early chest drain removal.Journal of thoracic disease · 2026Article
- Intraoperative Methadone Versus Epidural Analgesia for Perioperative Pain Management in Major Abdominal and Thoracic Surgery: A Retrospective Single-Center Study.Journal of clinical medicine · 2026Article
- Intraoperative Methadone for Post-craniotomy Pain Control: A Matched Cohort Exploratory Framework Study.Cureus · 2026Article
- Article
- Hypoxic brain damage in Methadone misuse: insights from MRI imaging and comparative study.Acta neurologica Belgica · 2025Article
- Intraoperative somatosensory evoked potential (SEP) monitoring: an updated position statement by the American Society of Neurophysiological Monitoring.Journal of clinical monitoring and computing · 2024Review
- Intraoperative Methadone and Postoperative Anesthesia Care Unit Outcomes: A Retrospective Cohort Analysis.Anesthesiology · 2024Article
- Comparison of low-dose ketamine to methadone for postoperative pain in opioid addicts: a randomized clinical trial.Anesthesia and pain medicine · 2024Article
- Natural Products Inhibition of Cytochrome P450 2B6 Activity and Methadone Metabolism.Drug metabolism and disposition: the biological fate of chemicals · 2024Article
- Intravenous methadone in the management of acute postoperative pain in a chronic cancer pain patient: A case report and review of the literature.Clinical case reports · 2023Article
- The Use of Parenteral Opioids in Cancer Pain Management.Cancers · 2023Article
- Intravenous Methadone for Perioperative and Chronic Cancer Pain: A Review of the Literature.Drugs · 2023Review
Corrections and comments
- Comment on
Authors and funding
1 author.
Evan D Kharasch
Funding
METHADONE AND HIV DRUG INTERACTIONSR01DA014211 · NIDA · WASHINGTON UNIVERSITY · PI KHARASCH, EVAN D. · 2001 to 2012
$4.8MADDICTION THERAPY: METABOLISM AND TRANSPORT-MEDIATED DRUG INTERACTIONSR01DA025931 · NIDA · WASHINGTON UNIVERSITY · PI KHARASCH, EVAN D. · 2008 to 2012
$1.7MOPIOIDS IN CANCER PAIN &DRUG ABUSE--OPTIMIZING THERAPYK24DA000417 · NIDA · WASHINGTON UNIVERSITY · PI KHARASCH, EVAN D. · 1999 to 2010
$1.4MNIDA NIH HHS K24 DA000417NIDA NIH HHS K24-DA00417NIDA NIH HHS R01 DA014211NIDA NIH HHS R01 DA025931NIDA NIH HHS R01-DA14211NIDA NIH HHS R01-DA25931
Abstract
PubMed holds no abstract for this paper.
Indexed as
HumansIntraoperative CareMethadonePostoperative PainMethadone
Identifiers
What OpenQuestion holds
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Registered trials
NCT02775474ClinicalTrials.gov
NCT06387303ClinicalTrials.gov
NCT06810336ClinicalTrials.gov
NCT07222072ClinicalTrials.gov
NCT07485803ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.