ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2011
Early natural history of incident, type-specific human papillomavirus infections in newly sexually active young women.
Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 2 of them syntheses that pooled it.
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Who cites it
69 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Association of female genital schistosomiasis and human papillomavirus and cervical pre-cancer: a systematic review.BMC women's health · 2025Pooled it
- Sexually Transmitted Infections Treatment Guidelines, 2021.MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports · 2021Guideline
- Trial
- Association Between Female Genital Schistosomiasis and High-Risk Human Papillomavirus Among Women of Reproductive Age in Zambia: The Schista Study.The Journal of infectious diseases · 2026Article
- SOX1/PAX1 Methylation for Triage of HPV-Positive Women in Cervical Cancer Screening: A Cohort Study.BJOG : an international journal of obstetrics and gynaecology · 2026Article
- A novel methylation marker on theFrontiers in oncology · 2026Article
- Distribution of High-Risk HPV in Cervical Versus Oropharyngeal Samples: Results from a Prospective Screening Study in a Cohort of European Women of Reproductive Age.Pathogens (Basel, Switzerland) · 2025Article
- Human papillomavirus (HPV) infection and liquid-based cytologic tests among cervical screening participants in Shannan City, Tibet, China, during 2021-2022.BMC infectious diseases · 2025Article
- Significance of non-steroidal anti-inflammatory drugs in the prevention and treatment of cervical cancer.Heliyon · 2025Review
- Impact of HIV infection on cervical intraepithelial neoplasia detection in pregnant and non-pregnant women in Germany: a cross-sectional study.Archives of gynecology and obstetrics · 2024Article
- Community intervention of a single-dose or 2-dose regimen of bivalent human papillomavirus vaccine in schoolgirls in Thailand: vaccine effectiveness 2 years and 4 years after vaccination.Journal of the National Cancer Institute. Monographs · 2024Article
- The Non-inferiority of Human Papillomavirus Vaccine Immunogenicity Among Women Over 26 Years: A Systematic Review.Cureus · 2024Review
- Human Papillomavirus Carcinogenicity and the Need of New Perspectives: Thoughts from a Retrospective Analysis on Human Papillomavirus Outcomes Conducted at the Hospital University of Bari, Apulia, Italy, between 2011 and 2022.Diagnostics (Basel, Switzerland) · 2024Article
- Prevalence and Genotyping of Human Papillomavirus Infections in Females and Males in Zhejiang, China.Infection and drug resistance · 2024Article
- Prevalence of High-Risk Human Papillomavirus Genotypes among Young Women in Puerto Rico; a retrospective longitudinal study.Research square · 2023Article
- HPV prevalence and genotype distribution among 38 056 women in Weifang, China: a cross-sectional study.BMJ open · 2023Article
- Cervicovaginal Gardnerella sialidase-encoding gene in persistent human papillomavirus infection.Scientific reports · 2023Article
- The Significance of Human Papillomavirus Receptors Related Genetic Variants in Cervical Cancer Screening.Microbiology spectrum · 2023Article
- Effect of a Multi-IngredientCancers · 2023Article
- Assessment of high-risk human papillomavirus infections and associated cervical dysplasia in HIV-positive pregnant women in Germany: a prospective cross-sectional two-centre study.Archives of gynecology and obstetrics · 2023Article
9 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors.
Funding
Abstract
backgroundCharacterizing short-term detection patterns of young women's incident α-genus human papillomavirus (HPV) infections may further our understanding of HPV transmission.
methodsBetween 2000 and 2007, we followed 18- to 22-year-old female university students with triannual HPV DNA and Papanicolaou testing. Using Kaplan-Meier methods, we estimated duration of detectable, type-specific incident infections; time to redetection (among infections that became undetectable); and time to cervical lesion development after incident infection. We evaluated risk factors for short-term persistent versus transient infection with logistic regression.
resultsThree hundred three incident, type-specific infections were detected in 85 sexually active women. Median time to first negative test after incident infection was 9.4 (95% CI: 7.8-11.2) months; 90.6% of infections became undetectable within 2 years. About 19.4% of infections that became undetectable were redetected within 1 year. Cervical lesions were common and 60% were positive for multiple HPV types in concurrent cervical swabs. Incident HPV detection in the cervix only (vs. the vulva/vagina only or both sites) was associated with short-term transience.
conclusionsAlthough most incident infections became undetectable within 2 years, redetection was common. Cervical lesions were a common early manifestation of HPV infection. IMPACT: It remains unclear whether potentially modifiable risk factors can be identified to reduce infection duration (and transmission likelihood).
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