ArticleVirchows Archiv. A, Pathological anatomy and histopathology1990
Left ventriculotomy of the heart: tissue repair and localization of collagen types I, II, III, IV, V, VI and fibronectin.
Article in Virchows Archiv. A, Pathological anatomy and histopathology, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 20 citations in OpenAlex.
- Cytokine-Mediated Alterations of Human Cardiac Fibroblast's Secretome.International journal of molecular sciences · 2021Article
- Matrix remodelling in dilated cardiomyopathy entails the occurrence of oncofetal fibronectin molecular variants.Heart (British Cardiac Society) · 1996Article
- Immunohistochemical localization of collagen types I and VI in human skin wounds.International journal of legal medicine · 1993Article
- Rapid expression of fibronectin in the rabbit heart after myocardial infarction with and without reperfusion.The Journal of clinical investigation · 1992Article
- Fibronectin expression in the normal and hypertrophic rat heart.The Journal of clinical investigation · 1992Article
- Microfilamentous type VI collagen in the hyalinized stroma of the hypertrophied ligamentum flavum.Virchows Archiv. A, Pathological anatomy and histopathology · 1991Article
- Differences between atrial and ventricular protein profiling in children with congenital heart disease.Molecular and cellular biochemistryArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The reparative process following left ventriculotomy was investigated immunohistochemically using anti-type I, II, III, IV, V and VI collagen antibodies, and anti-fibronectin antibody. Wound healing began with proliferation of young fibroblasts positive for type I, III and V collagens at the wound margin; vascular granulation tissue then grew into the injured myocardium followed by deposition of fibrous components immunoreactive with type I and III. At 30 days after operation when almost the entire thickness of the myocardium at the wound was replaced by fibrosing granulation tissue, a small cluster of adipocytes appeared around capillaries at the wound margin. The granulation tissue was gradually replaced by the adipose tissue with establishment of a fibrous union at the subendocardium by 90 days. In addition to type I and III collagens, type VI collagen was detected in a fine fibrillary pattern along thick collagen fibre bundles in the fibrous tissue and around the adipocytes. Fibronectin was distributed diffusely in the granulation tissue and gradually decreased with increase of the fibrous components. These results indicate that the ventriculotomy was finally repaired in the form of a fibrous scar, particularly in the endocardium. There was marked infiltration of adipose tissue in the damaged myocardium. Presumably type VI collagen, as well as type I and type III collagens, plays an important role in wound union.
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