ReviewThe Journal of experimental medicine2010
Induced pluripotent stem cell-derived human platelets: one step closer to the clinic.
Review in The Journal of experimental medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- Trial
- Overexpression of the pioneer transcription factor Nr5a2 promotes the development of mouse somatic cell nuclear transfer embryos.PLoS biology · 2026Article
- Toward in Vitro Production of Platelet from Induced Pluripotent Stem Cells.Stem cell reviews and reports · 2022Review
- Metabolic sensor O-GlcNAcylation regulates megakaryopoiesis and thrombopoiesis through c-Myc stabilization and integrin perturbation.Stem cells (Dayton, Ohio) · 2021Article
- Large-scale production of megakaryocytes in microcarrier-supported stirred suspension bioreactors.Scientific reports · 2018Article
- Induced Pluripotent Stem Cell-Derived Red Blood Cells and Platelet Concentrates: From Bench to Bedside.Cells · 2017Review
- Platelet generation in vivo and in vitro.SpringerPlus · 2016Review
- Using induced human pluripotent stem cells to study Diamond-Blackfan anemia: an outlook on the clinical possibilities.Expert review of hematology · 2013Article
- The aryl hydrocarbon receptor directs hematopoietic progenitor cell expansion and differentiation.Blood · 2013Article
- Induced pluripotency of human prostatic epithelial cells.PloS one · 2013Article
- Pluripotent stem cells reveal the developmental biology of human megakaryocytes and provide a source of platelets for clinical application.Cellular and molecular life sciences : CMLS · 2012Review
- Article
- Historical perspective and future directions in platelet research.Journal of thrombosis and haemostasis : JTH · 2011Review
- Advancements in reprogramming strategies for the generation of induced pluripotent stem cells.Journal of assisted reproduction and genetics · 2011Review
Corrections and comments
- Comment on
- Erratum issued
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The era of induced pluripotent stem (iPS) cells carries with it the promise of virtually unlimited sources of autologous cells for regenerative medicine. However, efficiently differentiating iPS cells into fully functional mature cell types remains challenging. A new study reporting the formation of fully functional platelets from human iPS (hiPS) cells improves upon recent efforts to generate this enucleated cell type, which remains in high demand for therapeutic transfusions. Notably, their lack of nucleus renders platelets unable to retain the pluripotent or tumorigenic properties of iPS cells.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.