ArticleThe Journal of physiology2011
Progesterone enhances adrenergic control of skin blood flow in women with high but not low orthostatic tolerance.
Article in The Journal of physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03236545 (Mechanisms of Vascular Dysfunction in Women), which is not on this map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Mechanisms of Vascular Dysfunction in Women: Role of Estradiol
Who cites it
22 citing papers in PubMed, 39 citations in OpenAlex.
- Guidelines on the use of sex and gender in cardiovascular research.American journal of physiology. Heart and circulatory physiology · 2024Review
- Hyperuricemia and Endothelial Function: Is It a Simple Association or Do Gender Differences Play a Role in This Binomial?Biomedicines · 2022Review
- Short-term salicylate treatment improves microvascular endothelium-dependent dilation in young adults with major depressive disorder.American journal of physiology. Heart and circulatory physiology · 2022Article
- Corrigendum: Estrogen to Progesterone Ratio and Fluid Regulatory Responses to Varying Degrees and Methods of Dehydration.Frontiers in sports and active living · 2022Article
- Influences of ovarian hormones on physiological responses to cold in women.Temperature (Austin, Tex.) · 2022Review
- Differential influences of dietary sodium on blood pressure regulation based on race and sex.Autonomic neuroscience : basic & clinical · 2021Review
- Confirmation of the cardiac safety of nolasiban in a randomised cohort of healthy female volunteers.Scientific reports · 2021Article
- Estrogen to Progesterone Ratio and Fluid Regulatory Responses to Varying Degrees and Methods of Dehydration.Frontiers in sports and active living · 2021Article
- Temperature regulation in women: Effects of the menstrual cycle.Temperature (Austin, Tex.) · 2020Review
- Sex differences in endothelial function important to vascular health and overall cardiovascular disease risk across the lifespan.American journal of physiology. Heart and circulatory physiology · 2018Review
- Ovarian hormones modulate endothelin-1 receptor responses in young women.Microcirculation (New York, N.Y. : 1994) · 2018Article
- Measurement of compensatory reserve predicts racial differences in tolerance to simulated hemorrhage in women.The journal of trauma and acute care surgery · 2018Article
- Hypothermia with Extreme Bradycardia following Spinal Cord Infarction of Septic Origin.Case reports in neurological medicine · 2017Article
- Menstrual cycle phase does not affect sympathetic neural activity in women with postural orthostatic tachycardia syndrome.The Journal of physiology · 2015Article
- Lack of limb or sex differences in the cutaneous vascular responses to exogenous norepinephrine.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- Challenges and methodology for testing young healthy women in physiological studies.American journal of physiology. Endocrinology and metabolism · 2014Article
- Sex differences in forearm vasoconstrictor response to voluntary apnea.American journal of physiology. Heart and circulatory physiology · 2014Article
- Mechanisms contributing to low orthostatic tolerance in women: the influence of oestradiol.The Journal of physiology · 2013Article
- Blood pressure regulation in women - differences emerge when challenged by orthostasis.The Journal of physiology · 2013Article
- Blood pressure and water regulation: understanding sex hormone effects within and between men and women.The Journal of physiology · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Women are more susceptible to orthostatic intolerance. Peripheral α-adrenergic responsiveness is important in orthostasis and is lower in women compared to men, and is modulated by female sex hormones. We tested the hypothesis that oestradiol attenuates peripheral cutaneous adrenergic responses in women with low orthostatic tolerance (LT), whereas progesterone enhances adrenergic responses in women with high orthostatic tolerance (HT). After completing a maximal lower body negative pressure test to determine level of orthostatic tolerance (cumulative stress index, CSI), women self administered a gonadotropin releasing hormone (GnRH) antagonist for 16 days to suppress endogenous sex hormone production. Oestradiol (E2, 0.2 mg day−1, patch; days 4–16), and progesterone (P4, 200 mg day−1, oral; days 12–16) were administered. Skin blood flow responses to graded intradermal microdialysis infusions of noradrenaline (NA) were measured during GnRH antagonist, E2, and E2+P4, in eight HT (s.e.m. = 22 ± 1 years, CSI −871 ± 86 mmHg min) and eight LT (21 ± 1 years, CSI −397 ± 65 mmHg min) women. In separate probes, NA was infused alone, and co-infused with the nitric oxide synthase inhibitor NG-monomethyl-l-arginine (l-NMMA, 10 mm), the non-selective cyclooxygenase inhibitor ketorolac tromethamine (Keto, 10 mm), and combined l-NMMA + Keto (10 mm each). Progesterone administration enhanced adrenergic responses in HT women (logEC50 GnRH −4.02 ± 0.39, E2+P4 −5.18 ± 0.31, P < 0.05); this response was reversed with Keto (E2+P4 logEC50 NA+Keto −3.82 ± 0.35, P < 0.05). In contrast, no change in adrenergic responsiveness occurred in LT women during any hormone condition. These data indicate differential regulation of cutaneous adrenergic responses by progesterone via the cyclooxygenase pathway in women with high and low orthostatic tolerance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.