ArticleReproduction (Cambridge, England)2011
Human ZP4 is not sufficient for taxon-specific sperm recognition of the zona pellucida in transgenic mice.
Article in Reproduction (Cambridge, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- Molecular interplay between sperm and oocyte: a narrative review.Human reproduction update · 2026Review
- Mutational disruption of transcription factors binding and regulatory networks in a case of unexplained total fertilization failure.Journal of translational medicine · 2025Article
- Cross-species insemination reveals mouse sperm ability to enter and cross the fish micropyle.eLife · 2025Article
- Genome-Wide Association Study Reveals Novel Candidate Genes Influencing Semen Traits in Landrace Pigs.Animals : an open access journal from MDPI · 2024Article
- Identification of Sperm-Binding Sites in the N-Terminal Domain of Bovine Egg Coat Glycoprotein ZP4.International journal of molecular sciences · 2022Article
- New Insights into the Mammalian Egg Zona Pellucida.International journal of molecular sciences · 2021Review
- Human Zona Pellucida Glycoproteins: Binding Characteristics With Human Spermatozoa and Induction of Acrosome Reaction.Frontiers in cell and developmental biology · 2021Review
- ZP4 Is Present in Murine Zona Pellucida and Is Not Responsible for the Specific Gamete Interaction.Frontiers in cell and developmental biology · 2020Article
- ZP4 confers structural properties to the zona pellucida essential for embryo development.eLife · 2019Article
- Molecular basis of egg coat cross-linking sheds light on ZP1-associated female infertility.Nature communications · 2019Article
- Glycan-Independent Gamete Recognition Triggers Egg Zinc Sparks and ZP2 Cleavage to Prevent Polyspermy.Developmental cell · 2018Article
- Egg Coat Proteins Across Metazoan Evolution.Current topics in developmental biology · 2018Review
- Sperm function tests in clinical practice.Turkish journal of urology · 2017Review
- ZP2 peptide beads select human sperm in vitro, decoy mouse sperm in vivo, and provide reversible contraception.Science translational medicine · 2016Article
- A single domain of the ZP2 zona pellucida protein mediates gamete recognition in mice and humans.The Journal of cell biology · 2014Article
- The maternal to zygotic transition in mammals.Molecular aspects of medicine · 2013Review
- The molecular basis of gamete recognition in mice and humans.Molecular human reproduction · 2013Review
- Human sperm bind to the N-terminal domain of ZP2 in humanized zonae pellucidae in transgenic mice.The Journal of cell biology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The molecular basis of human fertilization remains enigmatic. Mouse models are often used to study sperm-egg recognition, but the mouse zona pellucida surrounding ovulated eggs contains three proteins (ZP1, ZP2, and ZP3) whereas the human zona contains four (ZP1, ZP2, ZP3, and ZP4). Human sperm are fastidious and recognize human but not mouse eggs. Transgenic mouse lines were established to ascertain whether human ZP4 is the sole determinant of human sperm binding. Human ZP4 expressed in transgenic mice had a molecular mass similar to the range of native protein isoforms and was incorporated into the extracellular zona matrix. Transgenic females were fertile with normal litter sizes. Mouse sperm readily recognized transgenic ovulated eggs, but human sperm did not. We conclude that human ZP4 is not sufficient to support human sperm binding to the zona pellucida in transgenic mice and that other zona proteins may be needed for human gamete recognition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.