ArticleGenome research2011
Age-dependent gain of alternative splice forms and biased duplication explain the relation between splicing and duplication.
Article in Genome research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 65 citations in OpenAlex.
- An information content principle explains regulatory patterns of gene expression across human tissues.Nature communications · 2026Article
- Splicing retention and enhancer divergence govern the evolutionary fate of ohnologues following whole-genome duplication in rainbow trout.Scientific reports · 2026Article
- Maximum lifespan and brain size in mammals are associated with gene family size expansion related to immune system functions.Scientific reports · 2025Article
- Splicing complexity as a pivotal feature of alternative exons in mammalian species.BMC genomics · 2023Article
- Evolution of isoform-level gene expression patterns across tissues during lotus species divergence.The Plant journal : for cell and molecular biology · 2022Article
- Assessment of the Contribution of a Thermodynamic and Mechanical Destabilization of Myosin-Binding Protein C Domain C2 to the Pathomechanism of Hypertrophic Cardiomyopathy-Causing Double MutationInternational journal of molecular sciences · 2021Article
- PIC-Me: paralogs and isoforms classifier based on machine-learning approaches.BMC bioinformatics · 2021Article
- The divergence of alternative splicing between ohnologs in teleost fishes.BMC ecology and evolution · 2021Article
- Changes in Alternative Splicing in Response to Domestication and Polyploidization in Wheat.Plant physiology · 2020Article
- Article
- Loose ends: almost one in five human genes still have unresolved coding status.Nucleic acids research · 2018Article
- Complementarity of assembly-first and mapping-first approaches for alternative splicing annotation and differential analysis from RNAseq data.Scientific reports · 2018Article
- Review
- Alternative splicing and the evolution of phenotypic novelty.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- The Evolutionary Relationship between Alternative Splicing and Gene Duplication.Frontiers in genetics · 2017Review
- OGS2: genome re-annotation of the jewel wasp Nasonia vitripennis.BMC genomics · 2016Article
- The origin of exon 3 skipping of paternal GLOBOSA pre-mRNA in some Nicotiana tabacum lines correlates with a point mutation of the very last nucleotide of the exon.Molecular genetics and genomics : MGG · 2016Article
- Evidence for widespread subfunctionalization of splice forms in vertebrate genomes.Genome research · 2015Article
- The evolutionary fate of alternatively spliced homologous exons after gene duplication.Genome biology and evolution · 2015Article
- Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We analyze here the relation between alternative splicing and gene duplication in light of recent genomic data, with a focus on the human genome. We show that the previously reported negative correlation between level of alternative splicing and family size no longer holds true. We clarify this pattern and show that it is sufficiently explained by two factors. First, genes progressively gain new splice variants with time. The gain is consistent with a selectively relaxed regime, until purifying selection slows it down as aging genes accumulate a large number of variants. Second, we show that duplication does not lead to a loss of splice forms, but rather that genes with low levels of alternative splicing tend to duplicate more frequently. This leads us to reconsider the role of alternative splicing in duplicate retention.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.