ArticlePlant physiology2011
iTRAQ protein profile analysis of Arabidopsis roots reveals new aspects critical for iron homeostasis.
Article in Plant physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers.
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105 citing papers in PubMed, 234 citations in OpenAlex.
- Fungal Secretomics Through iTRAQ-Based Analysis.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Protein Phosphorylation Orchestrates Acclimations of Arabidopsis Plants to Environmental pH.Molecular & cellular proteomics : MCP · 2024Article
- Label-Free Quantitative Proteomics in Plant.Methods in molecular biology (Clifton, N.J.) · 2023Article
- A systematicFrontiers in plant science · 2023Article
- Effect of the Interaction between Elevated Carbon Dioxide and Iron Limitation on Proteomic Profiling of Soybean.International journal of molecular sciences · 2022Article
- POPEYE intercellular localization mediates cell-specific iron deficiency responses.Plant physiology · 2022Article
- Recent advances in proteomics and metabolomics in plants.Molecular horticulture · 2022Review
- Systematic analysis of the sugar accumulation mechanism in sucrose- and hexose- accumulating cherry tomato fruits.BMC plant biology · 2022Article
- Genomically Hardwired Regulation of Gene Activity Orchestrates Cellular Iron Homeostasis in Arabidopsis.RNA biology · 2022Article
- IRONMAN tunes responses to iron deficiency in concert with environmental pH.Plant physiology · 2021Article
- Genome-wide association study and transcriptome analysis reveal key genes affecting root growth dynamics in rapeseed.Biotechnology for biofuels · 2021Article
- Physiological and interactomic analysis reveals versatile functions of Arabidopsis 14-3-3 quadruple mutants in response to Fe deficiency.Scientific reports · 2021Article
- Combined Transcriptomic and Proteomic Analysis ofInsects · 2021Article
- Quantitative Proteomics and Transcriptomics Reveals Differences in Proteins During Anthers Development inFrontiers in plant science · 2021Article
- Effects of Excess Manganese on the Xylem Sap Protein Profile of Tomato (International journal of molecular sciences · 2020Article
- Hormonal regulation of root hair growth and responses to the environment in Arabidopsis.Journal of experimental botany · 2020Review
- Physiological and Proteomic Dissection of the Responses of Two Contrasting Wheat Genotypes to Nitrogen Deficiency.International journal of molecular sciences · 2020Article
- Changes in the microsomal proteome of tomato fruit during ripening.Scientific reports · 2019Article
- Article
- Comprehensive transcriptomics, proteomics, and metabolomics analyses of the mechanisms regulating tiller production in low-tillering wheat.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2019Article
45 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Iron (Fe) deficiency is a major constraint for plant growth and affects the quality of edible plant parts. To investigate the mechanisms underlying Fe homeostasis in plants, Fe deficiency-induced changes in the protein profile of Arabidopsis (Arabidopsis thaliana) roots were comprehensively analyzed using iTRAQ (Isobaric Tag for Relative and Absolute Quantification) differential liquid chromatography-tandem mass spectrometry on a LTQ-Orbitrap with high-energy collision dissociation. A total of 4,454 proteins were identified with a false discovery rate of less than 1.1%, and 2,882 were reliably quantified. A subset of 101 proteins was differentially expressed upon Fe deficiency. The changes in protein profiles upon Fe deficiency show low congruency with previously reported alterations in transcript levels, indicating posttranscriptional changes, and provide complementary information on Fe deficiency-induced processes. The abundance of proteins involved in the synthesis/regeneration of S-adenosylmethionine, the phenylpropanoid pathway, the response to oxidative stress, and respiration was highly increased by Fe deficiency. Using Fe-responsive proteins as bait, genome-wide fishing for partners with predictable or confirmed interologs revealed that RNA processing and ribonucleoprotein complex assembly may represent critical processes that contribute to the regulation of root responses to Fe deficiency, possibly by biasing translation efficiency.
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