ArticlePediatrics2011
Earliest appropriate time for administering neurobehavioral assessment in newborn infants.
Article in Pediatrics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00129324 (Neurobehavioral Effects of Prevalent Neurotoxicants in Children), which is not on this map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neurobehavioral Effects of Prevalent Neurotoxicants in Children: A Cohort Study of the Cincinnati Center for Children's Environmental Health
Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Infant neurobehavioural consequences of prenatal cigarette exposure: A systematic review and meta-analysis.Acta paediatrica (Oslo, Norway : 1992) · 2020Pooled it
- Neurobehavioral Profiles in Low-Risk Infants: Associations With Prenatal Maternal Biobehavior and Birth Characteristics.Developmental psychobiology · 2025Article
- The Clinical Value of Capillary Blood Cartridge-Based Testing in Neonatal Jitteriness: A Re-Evaluation of the Diagnostic Approach.Children (Basel, Switzerland) · 2025Article
- Continuum of neurobehaviour and its associations with brain MRI in infants born preterm.BMJ paediatrics open · 2017Article
- Assessment and evaluation of the high risk neonate: the NICU Network Neurobehavioral Scale.Journal of visualized experiments : JoVE · 2014Article
- Grandchild of the NBAS: the NICU network neurobehavioral scale (NNNS): a review of the research using the NNNS.Journal of child and adolescent psychiatric nursing : official publication of the Association of Child and Adolescent Psychiatric Nurses, Inc · 2013Review
- Case report: high prenatal bisphenol a exposure and infant neonatal neurobehavior.Environmental health perspectives · 2011Article
- Maternal smoking in pregnancy, fetal activity & newborn behavioral state: An observational ultrasound study.Neurotoxicology and teratologyArticle
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
objectiveTo assess the effect of examination time on newborn neurobehavioral examinations administered within 48 hours of delivery and to identify the earliest appropriate time for performing the assessment.
methodsWe analyzed data from neurobehavioral examinations on 324 newborns using the NICU Network Neurobehavioral Scale (NNNS). Trends over examination time and cumulative percentage within published normal ranges were analyzed to identify the earliest appropriate time for administering the examination. Ordinal logistic regression and multivariate regression were used for testing and defining the earliest appropriate time for administering the examination without being influenced by acute effects of labor and delivery while controlling for several potential confounding factors.
resultsThe arousal, excitability, lethargy, quality-of-movement, hypotonicity, and nonoptimal-reflexes scales were sensitive to timing of the examination. Results of ordinal logistic regression showed that 20 hours after delivery seemed to be the earliest appropriate time for administering newborn NNNS examinations. The proportion of NNNS scores within the normal range increased with time significantly when the examination was made less than 20 hours after delivery (n = 148) (odds ratio: 1.12 [95% confidence interval: 1.02-1.23]), but there was no longer significant association with time of examination after 20 hours (n = 176) (odds ratio: 1.04 [95% confidence interval: 0.99-1.09]). This result was confirmed by multivariate regression.
conclusionsWe recommend 20 hours after delivery as the earliest appropriate time for administering newborn NNNS examinations to obtain results reflecting outcomes that are a representative assessment of newborn neurobehavior and not contaminated by acute effects of labor and delivery.
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