ArticleJournal of clinical oncology : official journal of the American Society of Clinical Oncology2011
Racial differences in chronic immune stimulatory conditions and risk of non-Hodgkin's lymphoma in veterans from the United States.
Article in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- A systematic review of the incidence and prevalence of comorbidity in multiple sclerosis: overview.Multiple sclerosis (Houndmills, Basingstoke, England) · 2015Pooled it
- A systematic review of the incidence and prevalence of cancer in multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2015Pooled it
- Beyond the Usual Suspects: Emerging Associations Between Epstein-Barr Virus Infection/Infectious Mononucleosis and Cancers.Reviews in medical virology · 2026Review
- AllergoOncology: Role of immune cells and immune proteins.Clinical and translational allergy · 2022Review
- An overview of cancer health disparities: new approaches and insights and why they matter.Carcinogenesis · 2021Review
- Development and Validation of a Nomogram and a Comprehensive Prognostic Analysis of an LncRNA-Associated Competitive Endogenous RNA Network Based on Immune-Related Genes for Locally Advanced Rectal Cancer With Neoadjuvant Therapy.Frontiers in oncology · 2021Article
- Staging, Treatment, and Future Approaches of Gallbladder Carcinoma.Journal of gastrointestinal cancer · 2018Review
- Racial Differences in Cancer Susceptibility and Survival: More Than the Color of the Skin?Trends in cancer · 2017Review
- Allergic conditions are not associated with the risk of non-Hodgkin's lymphoma or Hodgkin's lymphoma: a systematic review and meta-analysis.OncoTargets and therapy · 2017Article
- Review
- Racial patterns of patients with primary mediastinal large B-cell lymphoma: SEER analysis.Medicine · 2016Article
- B cells gone rogue: the intersection of diffuse large B cell lymphoma and autoimmune disease.Expert review of hematology · 2016Review
- The inflammatory inception of gallbladder cancer.Biochimica et biophysica acta · 2016Review
- Relationship between ambient ultraviolet radiation and non-Hodgkin lymphoma subtypes: a U.S. population-based study of racial and ethnic groups.International journal of cancer · 2015Article
- Impact of CD4+ lymphocytes and HIV infection on Anti-Müllerian Hormone levels in a large cohort of HIV-infected and HIV-uninfected women.American journal of reproductive immunology (New York, N.Y. : 1989) · 2015Observational
- Racial differences in three major NHL subtypes: descriptive epidemiology.Cancer epidemiology · 2015Article
- Hypothetical Atopic Dermatitis-Myeloproliferative Neoplasm Syndrome.Frontiers in immunology · 2015Review
- Racial differences in mantle cell lymphoma in the United States.BMC cancer · 2014Article
- Allergic diseases and risk of hematopoietic malignancies in a cohort of postmenopausal women: a report from the Iowa Women's Health Study.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2014Article
- Common infection-related conditions and risk of lymphoid malignancies in older individuals.British journal of cancer · 2014Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
purposeTo examine underlying etiologic factors that may explain the racial disparity in non-Hodgkin's lymphoma (NHL) incidence patterns. PATIENTS AND
methodsWe assessed immune-related conditions and risk of developing NHL among more than 4 million hospitalized US veterans including 9,496 patients with NHL (7,999 white patients and 1,497 black patients) with up to 26 years of follow-up. We used time-dependent Poisson regression to estimate rate ratios (RRs) and 95% CIs for NHL risk among patients with a history of specific autoimmune diseases, infections, and allergies compared with patients without such history, adjusting for attained age, calendar year, race, number of hospital visits, and time between study entry and exit.
resultsPatients with infectious conditions had an increased risk of developing NHL (RR, 1.2; 95% CI, 1.1 to 1.2), particularly for gastrohepatic, genital, and systemic infectious conditions. Patients with autoimmune disease were generally more likely to develop NHL than patients without autoimmune disease, especially for conditions that typically present with detectable autoantibodies with systemic involvement (RR, 2.0; 95% CI, 1.8 to 2.2). Allergies were also associated with increased risk (RR, 1.4; 95% CI, 1.3 to 1.5). Although the risk of NHL was lower for blacks than whites (RR, 0.87; 95% CI, 0.82 to 0.92), blacks had a slightly higher risk of NHL associated with infections than whites (likelihood ratio test, P = .002) and a tendency toward higher risk associated with allergies (likelihood ratio test, P = .05). Risks associated with autoimmune conditions were similar by race (likelihood ratio test, P = .5).
conclusionThe observed difference in NHL risk by race supports a role for race-related differences in genes regulating immune/inflammatory response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.