Evidence map›Paper›PMID 2117279›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America1990

Complete sequence of the Drosophila nonmuscle myosin heavy-chain transcript: conserved sequences in the myosin tail and differential splicing in the 5' untranslated sequence.

A S Ketchum, C T Stewart, M Stewart, D P Kiehart

Open access · greenAbstract readComparative Study
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 57 citations in OpenAlex.

  1. Review
  2. eLife · 2016
    Article
  3. Article
  4. Article
  5. Amino-acid sequence of squid myosin heavy chain.Journal of muscle research and cell motility · 1998
    Article
  6. Article
  7. Article
  8. A myosin family reunion.Journal of muscle research and cell motility · 1996
    Review
  9. Essential light chain of Drosophila nonmuscle myosin II.Journal of muscle research and cell motility · 1995
    Article
  10. Article
  11. Scallop striated and smooth muscle myosin heavy-chain isoforms are produced by alternative RNA splicing from a single gene.Proceedings of the National Academy of Sciences of the United States of America · 1994
    Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

A S KetchumDepartment of Cellular and Developmental Biology, Harvard University, Cambridge, MA 02138.
C T Stewart
M Stewart
D P Kiehart
Harvard University · US

Funding

Morphogenesis: Biophysics and Genetics of Dorsal ClosureR01GM033830 · NIGMS · HARVARD UNIVERSITY · PI KIEHART, DANIEL PETER · 1985 to 2017
$7.2M
NIGMS NIH HHS GM-33830
6 · The paper itself

Abstract

We have sequenced a cDNA that encodes the nonmuscle myosin heavy chain from Drosophila melanogaster. An alternatively spliced exon at the 5' end generates two distinct heavy-chain transcripts: the longer transcripts inserts an additional start codon upstream of the primary translation start site and encodes a myosin heavy chain with a 45-residue extension at its amino terminus. The remainder of the coding sequence reveals extensive homology with other conventional myosins, especially metazoan nonmuscle and smooth muscle myosin isoforms. Comparisons among available myosin heavy-chain sequences establish that characteristic differences in sequence throughout the length of both the globular myosin head and extended rod-like tail readily distinguish nonmuscle and smooth muscle myosins from striated muscle isoforms and predict a basis for their functional diversity.

Indexed as

RNA SplicingTranscription, GeneticAmino Acid SequenceAnimalsBase SequenceDNADrosophila melanogasterGene LibraryMolecular Sequence DataMyosin SubfragmentsProtein ConformationSequence Homology, Nucleic AcidDNAMyosin Subfragments

Identifiers

PMID2117279
PMCPMC54524
OpenAlexW2094016161

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.