ArticleBone2011
Identification of secretory odontoblasts using DMP1-GFP transgenic mice.
Article in Bone, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 38 citations in OpenAlex.
- Specimen Shape and Elution Time Affect the Mineralization and Differentiation Potential of Dental Pulp Stem Cells to Biodentine.Journal of functional biomaterials · 2023Article
- Expression of secretory calcium-binding phosphoprotein (scpp) genes in medaka during the formation and replacement of pharyngeal teeth.BMC oral health · 2023Article
- Cellular Signaling for Dental Physiological Functions.Biomolecules · 2023Article
- Effects of CTHRC1 on odontogenic differentiation and angiogenesis in human dental pulp stem cells.Restorative dentistry & endodontics · 2023Article
- The Role of Cellular Metabolism in Maintaining the Function of the Dentine-Pulp Complex: A Narrative Review.Metabolites · 2023Review
- Role of the Demethylase AlkB Homolog H5 in the Promotion of Dentinogenesis.Frontiers in physiology · 2022Article
- Chitosan-Based Accelerated Portland Cement Promotes Dentinogenic/Osteogenic Differentiation and Mineralization Activity of SHED.Polymers · 2021Article
- The Regenerative Potential of bFGF in Dental Pulp Repair and Regeneration.Frontiers in pharmacology · 2021Review
- Chromatin Accessibility Predetermines Odontoblast Terminal Differentiation.Frontiers in cell and developmental biology · 2021Article
- Dental cell type atlas reveals stem and differentiated cell types in mouse and human teeth.Nature communications · 2020Article
- Expression of BSP-GFPtpz Transgene during Osteogenesis and Reparative Dentinogenesis.Journal of dental research · 2020Article
- Generation and characterization of DSPP-Cerulean/DMP1-Cherry reporter mice.Genesis (New York, N.Y. : 2000) · 2019Article
- Metformin Enhances the Differentiation of Dental Pulp Cells into Odontoblasts by Activating AMPK Signaling.Journal of endodontics · 2018Article
- FGF Signaling Prevents the Terminal Differentiation of Odontoblasts.Journal of dental research · 2017Article
- Alcohol Inhibits Odontogenic Differentiation of Human Dental Pulp Cells by Activating mTOR Signaling.Stem cells international · 2017Article
- Enhanced Dentinogenesis of Pulp Progenitors by Early Exposure to FGF2.Journal of dental research · 2015Article
- Article
- Stage-specific effects of fibroblast growth factor 2 on the differentiation of dental pulp cells.Cells, tissues, organs · 2014Article
- Treatment with chicken-egg-white or whole-egg extracts maintains and enhances the survival and differentiation of spleen cells.Cytotechnology · 2012Article
- A feasibility study for the analysis of reparative dentinogenesis in pOBCol3.6GFPtpz transgenic mice.International endodontic journal · 2012Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Terminal differentiation of odontoblasts from dental papilla is a long process involving several intermediate steps and changes in the transcriptional profile and expression of proteins secreted by cells in the odontoblast lineage. Transgenic mouse lines in which GFP expression is under the control of tissue- and stage specific promoters have provided powerful experimental tools for identification and isolation of cells at specific stages of differentiation along a lineage. Our previous studies showed utilization of pOBCol3.6GFP and pOBCol2.3GFP animals for identification of odontoblasts at early and late stages of polarization respectively. In the present study we used the DMP1-GFP transgenic animal as an experimental model to examine its expression during the differentiation of odontoblasts from progenitor cells in vivo and in vitro. Our observations showed that DMP1-GFP transgene is first activated in secretory/functional odontoblasts engaged in secretion of predentin and then transiently expressed at high levels in newly differentiated odontoblasts. Expression of DMP1-GFP was down-regulated in highly differentiated odontoblasts. The temporal and spatial pattern of expression of DMP1-GFP transgene closely mimics the expression of endogenous DMP1. This transgenic animal will facilitate studies of gene expression and biological functions in secretory/functional odontoblasts.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.