Evidence map›Paper›PMID 21172389›Full record

ArticleJournal of virological methods2011

Abbott RealTime HIV-1 m2000rt viral load testing: manual extraction versus the automated m2000sp extraction.

Lesley E Scott, John A Crump, Emma Msuya, Anne B Morrissey, Willem F Venter, Wendy S Stevens

Open access · greenAbstract readComparative Study
In one paragraph

Article in Journal of virological methods, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 23 citations in OpenAlex.

  1. Development and genomic characterization of a diverse HIV-1 variant reference panel for nucleic acid-based testing.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2026
    Article
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  8. Brucellosis among hospitalized febrile patients in northern Tanzania.The American journal of tropical medicine and hygiene · 2012
    Article
  9. Utility of rapid antibody tests to exclude HIV-1 infection among infants and children aged <18 months in a low-resource setting.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2012
    Article
  10. Article
  11. Chikungunya and dengue fever among hospitalized febrile patients in northern Tanzania.The American journal of tropical medicine and hygiene · 2012
    Article
  12. Leptospirosis among hospitalized febrile patients in northern Tanzania.The American journal of tropical medicine and hygiene · 2011
    Article
  13. Q fever, spotted fever group, and typhus group rickettsioses among hospitalized febrile patients in northern Tanzania.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2011
    Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 4 countries.

Lesley E ScottUniversity of the Witwatersrand, Department of Molecular Medicine and Haematology, School of Pathology, Faculty of Health Science, 7 York Rd Parktown, Johannesburg 2000, South Africa. lesley.scott@nhls.ac.za
John A Crump
Emma Msuya
Anne B Morrissey
Willem F Venter
Wendy S Stevens
University of the Witwatersrand · ZADuke Medical Center · USKilimanjaro Christian Medical Centre · TZ

Funding

Viral Sequencing CoreU19AI067854 · NIAID · DUKE UNIVERSITY · PI BHARDWAJ, NINA · 2006 to 2011
$290.5M
Viral and Host Determinants of HIV-1 TransmissionU01AI067854 · NIAID · DUKE UNIVERSITY · PI COHEN, MYRON S · 2005 to 2005
$14.9M
HIV/AIDS Clinical Trials UnitU01AI069484 · NIAID · DUKE UNIVERSITY · PI BARTLETT, JOHN A · 2007 to 2011
$14.6M
WOMEN'S HEALTH AGENDAU01AI039156 · NIAID · DUKE UNIVERSITY · PI BARTLETT, JOHN A · 1996 to 2006
$10.3M
International Clinical Trials UnitU01AI062563 · NIAID · DUKE UNIVERSITY · PI BARTLETT, JOHN A · 2004 to 2007
$4.0M
AIDS International Training and Research ProgramD43TW006732 · FIC · DUKE UNIVERSITY · PI BARTLETT, JOHN A · 2004 to 2012
$2.7M
FIC NIH HHS D43 TW006732NIAID NIH HHS AI 062563NIAID NIH HHS U01 AI039156NIAID NIH HHS U01 AI062563NIAID NIH HHS U01 AI067854NIAID NIH HHS U01 AI069484NIAID NIH HHS U01 AI069484-01NIAID NIH HHS U19 AI067854
6 · The paper itself

Abstract

The Abbott RealTime HIV-1 assay is a real-time nucleic acid amplification assay available for HIV-1 viral load quantitation. The assay has a platform for automated extraction of viral RNA from plasma or dried blood spot samples, and an amplification platform with real time fluorescent detection. Overall, this study found no clinically relevant differences in viral load, if samples were extracted manually.

Indexed as

HIV-1HIV InfectionsHumansReagent Kits, DiagnosticReproducibility of ResultsRNA, ViralSensitivity and SpecificityViral LoadReagent Kits, DiagnosticRNA, Viral

Identifiers

PMID21172389
PMCPMC3164890
OpenAlexW2075461127

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.