ArticlePhysiology & behavior2011
Individual differences in novelty-seeking behavior in rats as a model for psychosocial stress-related mood disorders.
Article in Physiology & behavior, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Rewarded Maze Training Increases Approach Behavior in Rats Through Neurogenesis-Dependent Growth of Ventral Hippocampus-Prelimbic Circuits.Biological psychiatry global open science · 2023Article
- Chronic mild stress paradigm as a rat model of depression: facts, artifacts, and future perspectives.Psychopharmacology · 2022Review
- Decreased Density of Perineuronal Net in Prelimbic Cortex Is Linked to Depressive-Like Behavior in Young-Aged Rats.Frontiers in molecular neuroscience · 2020Article
- Behavioral Traits Associated With Resilience to the Effects of Repeated Social Defeat on Cocaine-Induced Conditioned Place Preference in Mice.Frontiers in behavioral neuroscience · 2019Article
- Differential stress induced c-Fos expression and identification of region-specific miRNA-mRNA networks in the dorsal raphe and amygdala of high-responder/low-responder rats.Behavioural brain research · 2017Article
- Neuroinflammation at the interface of depression and cardiovascular disease: Evidence from rodent models of social stress.Neurobiology of stress · 2016Review
- Prediction of individual differences in fear response by novelty seeking, and disruption of contextual fear memory reconsolidation by ketamine.Neuropharmacology · 2016Article
- Sex Differences in Effects of Ketamine on Behavior, Spine Density, and Synaptic Proteins in Socially Isolated Rats.Biological psychiatry · 2016Article
- Cognitive Dysfunction in Major Depressive Disorder. A Translational Review in Animal Models of the Disease.Pharmaceuticals (Basel, Switzerland) · 2016Review
- Resilience to the effects of social stress: evidence from clinical and preclinical studies on the role of coping strategies.Neurobiology of stress · 2015Article
- Epigenetic mechanisms underlying the role of brain-derived neurotrophic factor in depression and response to antidepressants.The Journal of experimental biology · 2015Review
- Forced swim test induces divergent global transcriptomic alterations in the hippocampus of high versus low novelty-seeker rats.Human genomics · 2014Article
- Basal variability in CREB phosphorylation predicts trait-like differences in amygdala-dependent memory.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Paradoxical tolerance to cocaine after initial supersensitivity in drug-use-prone animals.The European journal of neuroscience · 2013Article
- Individual differences in novelty seeking predict subsequent vulnerability to social defeat through a differential epigenetic regulation of brain-derived neurotrophic factor expression.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Highly impulsive rats: modelling an endophenotype to determine the neurobiological, genetic and environmental mechanisms of addiction.Disease models & mechanisms · 2013Review
- Differential brain-derived neurotrophic factor expression in limbic brain regions following social defeat or territorial aggression.Behavioral neuroscience · 2011Article
- Differential effects of social defeat in rats with high and low locomotor response to novelty.Neuroscience · 2011Article
- Perceived Stress in Older Dementia Caregivers: Mediation by Loneliness and Depression.American journal of Alzheimer's disease and other dementiasArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Most neuropsychiatric disorders, including stress-related mood disorders, are complex multi-parametric syndromes. Diagnoses are therefore hard to establish and current therapeutic strategies suffer from significant variability in effectiveness, making the understanding of inter-individual variations crucial to unveiling effective new treatments. In rats, such individual differences are observed during exposure to a novel environment, where individuals will exhibit either high or low locomotor activity and can thus be separated into high (HR) and low (LR) responders, respectively. In rodents, a long-lasting, psychosocial, stress-induced depressive state can be triggered by exposure to a social defeat procedure. We therefore analyzed the respective vulnerabilities of HR and LR animals to long-lasting, social defeat-induced behavioral alterations relevant to mood disorders. Two weeks after four daily consecutive social defeat exposures, HR animals exhibit higher anxiety levels, reduced body weight gain, sucrose preference, and a marked social avoidance. LR animals, however, remain unaffected. Moreover, while repeated social defeat exposure induces long-lasting contextual fear memory in both HR and LR animals, only HR individuals exhibit marked freezing behavior four weeks after a single social defeat. Combined, these findings highlight the critical involvement of inter-individual variations in novelty-seeking behavior in the vulnerability to stress-related mood disorders, and uncover a promising model for posttraumatic stress disorder.
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