ArticleJournal of Crohn's & colitis2008
Reconsidering the methodology of "stress" research in inflammatory bowel disease.
Article in Journal of Crohn's & colitis, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Systematic review: the role of psychological stress in inflammatory bowel disease.Alimentary pharmacology & therapeutics · 2022Pooled it
- Gut-directed hypnotherapy significantly augments clinical remission in quiescent ulcerative colitis.Alimentary pharmacology & therapeutics · 2013Trial
- Optimizing management of Crohn's disease within a project management framework: results of a pilot study.Inflammatory bowel diseases · 2012Trial
- The potential role of a self-management intervention for ulcerative colitis: a brief report from the ulcerative colitis hypnotherapy trial.Biological research for nursing · 2012Trial
- Mediating Role of Negative Affectivity in the Association Between Lifetime Trauma and Gastrointestinal Symptoms.Healthcare (Basel, Switzerland) · 2025Article
- Burden of Common Mental Disorders in Ulcerative Colitis and Irritable Bowel Syndrome Patients: An Analysis of Risk Factors.Journal of clinical medicine · 2025Article
- Inflammatory Bowel Disease Disability Index is a valid and reliable measure of disability in an English-speaking hospital practice and predicts long-term requirement for treatment escalation.Frontline gastroenterology · 2024Article
- The Interaction between Stress and Inflammatory Bowel Disease in Pediatric and Adult Patients.Journal of clinical medicine · 2024Review
- Psychiatric Comorbidities of Inflammatory Bowel Disease: It Is a Matter of Microglia's Gut Feeling.Cells · 2024Review
- Correlation of mental and psychological status with disease activity in patients with inflammatory bowel disease using SCL-90 R Questionnaire.Przeglad gastroenterologiczny · 2024Article
- Delivery Strategies of Probiotics from Nano- and Microparticles: Trends in the Treatment of Inflammatory Bowel Disease-An Overview.Pharmaceutics · 2023Review
- Mental Illnesses in Inflammatory Bowel Diseases:Medicina (Kaunas, Lithuania) · 2023Review
- Burden of depression and anxiety among patients with inflammatory bowel disease: results of a nationwide analysis.International journal of colorectal disease · 2022Article
- High Levels of Psychological Resilience Associated With Less Disease Activity, Better Quality of Life, and Fewer Surgeries in Inflammatory Bowel Disease.Inflammatory bowel diseases · 2021Article
- Life Stressors in Patients with Inflammatory Bowel Disease: Comparison with a Population-Based Healthy Control Group in the Czech Republic.International journal of environmental research and public health · 2021Article
- A Review of Inflammatory Bowel Disease: A Model of Microbial, Immune and Neuropsychological Integration.Public health reviews · 2021Review
- Melatonin Alleviates Neuroinflammation and Metabolic Disorder in DSS-Induced Depression Rats.Oxidative medicine and cellular longevity · 2020Article
- Aggravated mucosal and immune damage in a mouse model of ulcerative colitis with stress.Experimental and therapeutic medicine · 2019Article
- Anxiety, depression, and inflammation after restorative proctocolectomy.International journal of colorectal disease · 2018Article
- Assessing the Relationship between Sources of Stress and Symptom Changes among Persons with IBD over Time: A Prospective Study.Canadian journal of gastroenterology & hepatology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
BACKGROUND AND
aimsThe goals of this paper are: 1) to critically review and analyze the methodology of the studies since 1990 linking stress to inflammatory bowel disease; and 2) to make recommendations for future research in this area of research.
methodsArticles were restricted to empirical reports in the English language with human subjects. Eleven empirical articles were able to answer "How is psychological stress related to inflammation and/or the expression or course of inflammatory bowel disease?"
resultsStudies varied by choice of participant groups, method for classifying disease activity, choice of design, and definition and measurement of stress. Only half of the studies supported the hypothesis that stress affected IBD in some way.
conclusionsCurrent methodological limitations in the stress and gut inflammation research have made it difficult for us to ascertain the role of stress in inflammatory bowel disease. Authors provide a checklist of items to consider when designing future studies.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.