ArticleJournal of Crohn's & colitis2007
Probiotics for preventing relapse or recurrence in Crohn's disease involving the ileum: Are there reasons for failure?
Article in Journal of Crohn's & colitis, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 15 citations in OpenAlex.
- The Impact of Probiotics on Clinical Outcomes in Diverticular Disease: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2025Review
- Prevention and Alleviation of Dextran Sulfate Sodium Salt-Induced Inflammatory Bowel Disease in Mice WithFrontiers in microbiology · 2020Article
- Probiotics and prebiotics in intestinal health and disease: from biology to the clinic.Nature reviews. Gastroenterology & hepatology · 2019Review
- Article
Corrections and comments
- Expression of concern · 2022-01-24Civil Proceedings · Concerns/Issues about Data · Concerns/Issues about Results and/or Conclusions · Legal Reasons and/or Threats · · See also: https://doi.org/10.1093/ecco-jcc/jjab225 Journal was previously published by Elsevier until 2015.
- Commented on by
- Erratum issuedCorrection.2023
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In contrast to ulcerative colitis and pouchitis, benefits of probiotic therapy in preventing recurrence/relapse in Crohn's disease (mostly involving the ileum) are far from being proven. The lack of response in this setting does not seem attributable to a lower relevance of dysbiosis in ileal Crohn's disease, since this - or at least the presence of increased mucosal amounts of potentially pathogen bacteria - has been proven to occur in the ileum of Crohn's disease patients. Available data indicate that whereas in ulcerative colitis (and to a lesser extent in colonic Crohn's disease) the innate immune response is enhanced, it is constitutively depressed in ileal Crohn's disease. Therefore, attempts to modify the composition of intestinal microflora in colonic IBD or pouchitis by means of probiotics do make sense. In contrast, supplying additional bacteria (even being probiotics) to an ileum with decreased antibacterial defence does not seem reasonable. In fact, the presence of intestinal contents has been reported to be related to postoperative recurrence in ileo-caecal Crohn's disease, and antibiotic treatment in effective to prevent its development.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.