ArticleJournal of biomedical materials research. Part A2011
Fibrin microthreads support mesenchymal stem cell growth while maintaining differentiation potential.
Article in Journal of biomedical materials research. Part A, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
22 citing papers in PubMed.
- Immunomodulatory Delivery Materials for Tissue Repair.Advanced healthcare materials · 2025Review
- Biocompatibility of decellularized spinach leaves.npj biomedical innovations · 2025Article
- A Novel Pulmonary Valve Replacement Surgery Strategy Using Contracting Band for Patients With Repaired Tetralogy of Fallot: An MRI-Based Multipatient Modeling Study.Frontiers in bioengineering and biotechnology · 2021Article
- Etching anisotropic surface topography onto fibrin microthread scaffolds for guiding myoblast alignment.Journal of biomedical materials research. Part B, Applied biomaterials · 2020Article
- Horseradish Peroxidase-Catalyzed Crosslinking of Fibrin Microthread Scaffolds.Tissue engineering. Part C, Methods · 2020Article
- Multi-Band Surgery for Repaired Tetralogy of Fallot Patients With Reduced Right Ventricle Ejection Fraction: A Pilot Study.Frontiers in physiology · 2020Article
- Adipose-derived stromal cell secreted factors induce the elastogenesis cascade within 3D aortic smooth muscle cell constructs.Matrix biology plus · 2019Article
- The Advancement of Biomaterials in Regulating Stem Cell Fate.Stem cell reviews and reports · 2018Review
- Development of a Contractile Cardiac Fiber From Pluripotent Stem Cell Derived Cardiomyocytes.Frontiers in cardiovascular medicine · 2018Article
- Delivering stem cells to the healthy heart on biological sutures: effects on regional mechanical function.Journal of tissue engineering and regenerative medicine · 2017Article
- Heparinized collagen sutures for sustained delivery of PDGF-BB: Delivery profile and effects on tendon-derived cells In-Vitro.Acta biomaterialia · 2016Article
- The Effect of Sterilization Methods on the Structural and Chemical Properties of Fibrin Microthread Scaffolds.Macromolecular bioscience · 2016Article
- Designing Biopolymer Microthreads for Tissue Engineering and Regenerative Medicine.Current stem cell reports · 2016Article
- Functional Effects of Delivering Human Mesenchymal Stem Cell-Seeded Biological Sutures to an Infarcted Heart.BioResearch open access · 2016Article
- Static axial stretching enhances the mechanical properties and cellular responses of fibrin microthreads.Acta biomaterialia · 2014Article
- The cardiac muscle duplex as a method to study myocardial heterogeneity.Progress in biophysics and molecular biology · 2014Review
- A Multiphysics Modeling Approach to Develop Right Ventricle Pulmonary Valve Replacement Surgical Procedures with a Contracting Band to Improve Ventricle Ejection Fraction.Computers & structures · 2013Article
- The modulation of endothelial cell morphology, function, and survival using anisotropic nanofibrillar collagen scaffolds.Biomaterials · 2013Article
- A novel suture-based method for efficient transplantation of stem cells.Journal of biomedical materials research. Part A · 2013Article
- Using contracting band to improve right ventricle ejection fraction for patients with repaired tetralogy of Fallot: a modeling study using patient-specific CMR-based 2-layer anisotropic models of human right and left ventricles.The Journal of thoracic and cardiovascular surgery · 2013Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
We developed a method to produce discrete fibrin microthreads, which can be seeded with human mesenchymal stem cells (hMSCs) and used as a suture to enhance the efficiency and localization of cell delivery. To assess the efficacy of fibrin microthreads to support hMSC attachment, proliferation, and survival, microthreads (100 μm diameter per microthread) were bundled together, seeded with 50,000 hMSCs for 2 h, and cultured for 5 days. Cell density on microthread bundles increased over time in culture to a maximum average density of 731 ± 101 cells/mm(2) after 5 days. A LIVE/DEAD assay confirmed that the cells were viable, and Ki-67 staining verified hMSC proliferation. In addition, functional differentiation assays demonstrated that hMSCs cultured on microthreads retained their ability to differentiate into adipocytes and osteocytes. The results of this study demonstrate that fibrin microthreads support hMSC viability and proliferation, while maintaining their multipotency. We anticipate that these cell-seeded fibrin microthreads will serve as a platform technology to improve localized delivery and engraftment of viable cells to damaged tissue.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.